US 12,448,388 B2
PRMT5 inhibitors and uses thereof
Megan K. Armstrong, San Francisco, CA (US); Elbert Chin, San Mateo, CA (US); Chienhung Chou, Dublin, CA (US); Laurent P. Debien, San Francisco, CA (US); Yifan Deng, Milpitas, CA (US); Joshua D. Farr, Mountain View, CA (US); Pancham Lal Gupta, Foster City, CA (US); Chao-I Hung, San Mateo, CA (US); Benjamin J. June, San Francisco, CA (US); Prasenjit K. Mukherjee, South San Francisco, CA (US); Shaina V. Nguyen, Yorba Linda, CA (US); Gregory T. Notte, Redwood City, CA (US); Daniel Roa, Foster City, CA (US); Adam J. Schrier, Redwood City, CA (US); Katie A. Spence, San Francisco, CA (US); and Zheng-Yu Yang, Palo Alto, CA (US)
Assigned to Gilead Sciences, Inc., Foster City, CA (US)
Filed by Gilead Sciences, Inc., Foster City, CA (US)
Filed on May 14, 2024, as Appl. No. 18/663,952.
Application 18/663,952 is a continuation of application No. 18/641,180, filed on Apr. 19, 2024, abandoned.
Claims priority of provisional application 63/551,246, filed on Feb. 8, 2024.
Claims priority of provisional application 63/497,683, filed on Apr. 21, 2023.
Prior Publication US 2024/0376110 A1, Nov. 14, 2024
Int. Cl. C07D 487/04 (2006.01); A61K 31/4985 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/5377 (2006.01); A61K 31/538 (2006.01); A61K 31/5383 (2006.01); A61K 31/5386 (2006.01); A61K 31/55 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07D 487/14 (2006.01); C07D 519/00 (2006.01)
CPC C07D 487/04 (2013.01) [A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 31/538 (2013.01); A61K 31/5383 (2013.01); A61K 31/5386 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 487/14 (2013.01); C07D 519/00 (2013.01)] 18 Claims
 
1. A compound of Formula (I)

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein
R is

OG Complex Work Unit Chemistry
R3a is H;
R3b is H or CH3;
Y1 is N, CH, or CF;
—NR1R2 is

OG Complex Work Unit Chemistry
each Z6 is independently F, —CH3, —CF3, —C2F5, or —OCF3; and
p is 1 or 2.