US 12,448,376 B2
Phenothiazine ferroptosis inhibitor, preparation method therefor and application thereof
Shengyong Yang, Sichuan (CN); and Linli Li, Sichuan (CN)
Assigned to CHENGDU HENGHAO INNOVATIVE SCIENCE AND TECHNOLOGY CO., LTD., Sichuan (CN)
Appl. No. 17/778,831
Filed by CHENGDU HENGHAO INNOVATIVE SCIENCE AND TECHNOLOGY CO., LTD., Sichuan (CN)
PCT Filed Nov. 18, 2020, PCT No. PCT/CN2020/129707
§ 371(c)(1), (2) Date May 21, 2022,
PCT Pub. No. WO2021/098715, PCT Pub. Date May 27, 2021.
Claims priority of application No. 201911150501.7 (CN), filed on Nov. 21, 2019.
Prior Publication US 2023/0021442 A1, Jan. 26, 2023
Int. Cl. C07D 471/04 (2006.01); A61P 9/10 (2006.01); C07D 417/06 (2006.01); C07D 417/10 (2006.01); C07D 495/04 (2006.01)
CPC C07D 471/04 (2013.01) [A61P 9/10 (2018.01); C07D 417/06 (2013.01); C07D 417/10 (2013.01); C07D 495/04 (2013.01)] 9 Claims
 
1. A compound represented by formula IV, a salt thereof, or a stereoisomer thereof:

OG Complex Work Unit Chemistry
wherein,
ring B is selected from 5- to 6-membered unsaturated heterocyclyl independently substituted by n R2;
n is an integer of 0˜3;
each R2 is independently selected from substituted or unsubstituted C1˜C3 alkyl, halogen, amino, —C(O)NR3R4, —C(O)R5 and —C(O)OR5; or two R2 on the same carbon atom constitute ═O;
R3 and R4 are independently selected from hydrogen, substituted C1˜C2 alkyl, and substituted aryl;
R5 is independently selected from hydrogen and C1˜C2 alkyl;
the substituent of the alkyl is selected from substituted or unsubstituted 5- to 6-membered saturated heterocyclyl, 4- to 6-membered saturated cycloalkyl, —NR6R7, aryl, naphthyl, and C1˜C3 alkoxy;
R6 and R7 are independently selected from C˜C3 alkyl;
the substituent of the saturated heterocyclyl is selected from C1˜C8 alkyl and —C(O) OR5;
the substituent of the aryl is selected from C1˜C2 alkyl and nitro; and
the heteroatom of the heterocyclyl is selected from N, O and S.