US 12,448,364 B2
2, 4-diaminopyrimidine derivative and application thereof
Lei Zhang, Zheijang (CN)
Assigned to Shanghai Zheye Biotechnology Co., Ltd., Shanghai (CN)
Appl. No. 17/418,550
Filed by Shanghai Zheye Biotechnology Co., Ltd., Shanghai (CN)
PCT Filed Dec. 25, 2019, PCT No. PCT/CN2019/128245
§ 371(c)(1), (2) Date Feb. 21, 2022,
PCT Pub. No. WO2020/135488, PCT Pub. Date Jul. 2, 2020.
Claims priority of application No. 201811594666.9 (CN), filed on Dec. 26, 2018.
Prior Publication US 2022/0177448 A1, Jun. 9, 2022
Int. Cl. C07D 401/14 (2006.01); C07D 405/14 (2006.01)
CPC C07D 401/14 (2013.01) [C07D 405/14 (2013.01)] 7 Claims
 
1. A compound represented by formula (III), or pharmaceutically acceptable salts, hydrates, or stereoisomers thereof, wherein formula (III) is

OG Complex Work Unit Chemistry
wherein,

OG Complex Work Unit Chemistry
is selected from the group consisting of

OG Complex Work Unit Chemistry
R1 is

OG Complex Work Unit Chemistry
wherein R13 is selected from the group consisting of —H and -methyl;
R2 is selected from the group consisting of —H and methyl;
R3 and R4 are each independently selected from the group consisting of —H, halogen, methyl, and methoxy; and
R5 is selected from the group consisting of —H, halogen, methyl, and methoxy.