US 12,447,470 B2
Devices, systems, and methods for performing optical assays
Michael Louie Low, Kendall Park, NJ (US); Barry Bass, Bridgewater, NJ (US); and Sergey Gershtein, Skillman, NJ (US)
Assigned to Abbott Point of Care Inc., Princeton, NJ (US)
Filed by Abbott Point of Care Inc., Princeton, NJ (US)
Filed on Dec. 23, 2021, as Appl. No. 17/645,797.
Application 17/645,797 is a continuation of application No. 16/104,232, filed on Aug. 17, 2018, granted, now 11,253,852.
Claims priority of provisional application 62/546,713, filed on Aug. 17, 2017.
Prior Publication US 2022/0113246 A1, Apr. 14, 2022
Int. Cl. B01L 1/00 (2006.01); B01L 3/00 (2006.01); G01N 21/03 (2006.01); G01N 21/31 (2006.01); G01N 21/75 (2006.01); G01N 21/78 (2006.01); G01N 27/327 (2006.01); G01N 27/416 (2006.01); G01N 33/487 (2006.01); G01N 33/49 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01)
CPC B01L 3/502715 (2013.01) [B01L 3/502753 (2013.01); B01L 3/545 (2013.01); G01N 21/03 (2013.01); G01N 21/3151 (2013.01); G01N 21/75 (2013.01); G01N 21/78 (2013.01); G01N 27/3273 (2013.01); G01N 27/416 (2013.01); G01N 33/48785 (2013.01); G01N 33/492 (2013.01); G01N 33/50 (2013.01); G01N 33/5302 (2013.01); B01L 2200/0605 (2013.01); B01L 2200/10 (2013.01); B01L 2200/143 (2013.01); B01L 2300/021 (2013.01); B01L 2300/0645 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/087 (2013.01); B01L 2400/0481 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/0683 (2013.01); B01L 2400/0688 (2013.01); G01N 2021/0328 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method for performing an optical assay and at least one of: an amperometric analyte assay, a potentiometric analyte assay, and a conductometric assay on a biological sample, the method comprising:
inserting a test cartridge comprising a plurality of discrete connector contacts, a light emitter, and a light detector into a port of an analyzer, the analyzer comprising: a multi-terminal connector, a universal channel circuitry with one or more electronic switches electrically connected to the multi-terminal connector thereby bringing the multi-terminal connector in electrical contact with the plurality of discrete connector contacts, and a non-transitory machine readable memory coupled to a processor, wherein the memory is encoded with a set of instructions, which when executed by the processor cause the analyzer to perform the optical assay and at least one of: the amperometric analyte assay, the potentiometric analyte assay, and the conductometric assay;
after the inserting the test cartridge, prompting the processor to execute the instructions from the memory to cause the analyzer to:
perform the optical assay using the optical sensor current measurement mode by:
instructing the one or more electronic switches to arrange in an optical sensor current measurement mode, comprising (i) electrically connecting the universal channel circuitry to the light emitter via at least one of the plurality of discrete connector contacts and the multi-terminal connector, (ii) electrically connecting the universal channel circuitry to the light detector via at least another one of the plurality of discrete connector contacts and the multi-terminal connector;
driving the light emitter to project light into a portion of a conduit of the test cartridge comprising an analyte assay region;
converting an output signal of the light detector to a signal proportional to light received from the portion of the conduit; and
perform at least one of:
the amperometric analyte assay using the amperometric measurement mode by arranging the electronic switches of the universal channel circuitry to connect the universal channel circuitry to the amperometric electrode,
the potentiometric analyte assay using the potentiometric measurement mode by arranging the electronic switches of the universal channel circuitry to connect the universal channel circuitry to the potentiometric electrode, or
the conductometric assay using the conductometric measurement mode by arranging the electronic switches of the universal channel circuitry to connect the universal channel circuitry to the conductometric electrode.