US 12,447,357 B2
Noninvasive imaging and treatment system for cardiac arrhythmias
Clifford G. Robinson, Chesterfield, MO (US); and Phillip S. Cuculich, St. Louis, MO (US)
Assigned to Washington University, St. Louis, MO (US)
Filed by Washington University, St. Louis, MO (US)
Filed on Jul. 14, 2022, as Appl. No. 17/812,594.
Application 17/812,594 is a continuation of application No. 15/773,415, granted, now 11,406,845, previously published as PCT/US2016/000103, filed on Nov. 7, 2016.
Claims priority of provisional application 62/252,104, filed on Nov. 6, 2015.
Prior Publication US 2022/0362579 A1, Nov. 17, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 5/10 (2006.01); A61B 5/00 (2006.01); A61B 6/00 (2024.01); A61B 6/50 (2024.01); A61B 8/00 (2006.01); A61B 5/282 (2021.01); A61B 5/318 (2021.01); A61B 6/03 (2006.01); A61B 8/08 (2006.01); A61B 18/00 (2006.01); A61N 5/00 (2006.01); G16H 30/40 (2018.01)
CPC A61N 5/1039 (2013.01) [A61B 6/503 (2013.01); A61B 6/5247 (2013.01); A61B 8/5261 (2013.01); A61B 5/282 (2021.01); A61B 5/318 (2021.01); A61B 6/032 (2013.01); A61B 8/0883 (2013.01); A61B 8/483 (2013.01); A61B 8/488 (2013.01); A61B 18/00 (2013.01); A61B 2576/023 (2013.01); A61N 5/00 (2013.01); A61N 5/10 (2013.01); A61N 5/1068 (2013.01); A61N 5/1083 (2013.01); G16H 30/40 (2018.01)] 16 Claims
OG exemplary drawing
 
1. A noninvasive system for imaging, planning, and treating cardiac arrhythmia in a subject, the system comprising:
a noninvasive means for imaging a heart of the subject and identifying an arrhythmia comprising:
an array of body surface electrodes for noninvasively measuring electrical potentials at a plurality of locations on the subject to identify the arrhythmia, and
a geometry determining device for noninvasively obtaining a heart-torso geometry of the subject comprising an image data type;
an imaging processor configured to compute heart electrical activity data and generate an image of the heart from the electrical potentials measured by the array of body surface electrodes and the heart-torso geometry obtained by the geometry determining device;
a treatment planning system for developing a noninvasive treatment plan for the arrhythmia based on the electrical potentials measured by the array of body surface electrodes and the heart-torso geometry obtained by the geometry determining device, the treatment planning system configured to:
import an arrhythmia target defined relative to the image of the heart generated by the imaging processor; and
register the imported arrhythmia target to a primary planning dataset;
a converting processor for converting the defined arrhythmia target into image data of the image data type generated by the geometry determining device; and
a noninvasive means for treating the arrhythmia programmed to treat the arrhythmia by directing a noninvasive therapy to one or more target regions of the heart of the subject according to the noninvasive treatment plan developed by the treatment planning system, wherein the treatment planning system is configured to import the arrhythmia target as image data of the image data type generated by the geometry determining device, and to register the arrhythmia target to the primary dataset by registering the imported image data to the primary planning dataset having the same image data type as the image data type generated by the geometry determining device, and wherein the noninvasive means for treating the arrhythmia comprises one of stereotactic body radiotherapy, stereotactic ablative radiotherapy, stereotactic radiosurgery, fractionated radiotherapy, hypofractionated radiotherapy, high-frequency/focused ultrasound, or lasers.