US 12,447,256 B2
Blood separation by microfluidic acoustic focusing
Jason O. Fiering, Boston, MA (US); Shivshanker Sundaram, Tampa, FL (US); and Andrew Meuller, Somerville, MA (US)
Assigned to The Charles Stark Draper Laboratory, Inc.
Filed by The Charles Stark Draper Laboratory, Inc., Cambridge, MA (US)
Filed on Mar. 14, 2023, as Appl. No. 18/121,192.
Application 18/121,192 is a division of application No. 16/236,404, filed on Dec. 29, 2018, granted, now 11,617,820.
Application 16/236,404 is a continuation of application No. 14/772,216, granted, now 10,166,323, previously published as PCT/US2014/022701, filed on Mar. 10, 2014.
Claims priority of provisional application 61/775,233, filed on Mar. 8, 2013.
Prior Publication US 2023/0218813 A1, Jul. 13, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61M 1/36 (2006.01); B01D 21/28 (2006.01)
CPC A61M 1/3693 (2013.01) [A61M 1/362 (2014.02); A61M 1/3678 (2014.02); A61M 1/3692 (2014.02); B01D 21/28 (2013.01); B01D 21/283 (2013.01); B01D 2221/10 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A method of cleansing blood comprising:
flowing whole blood, including plasma, a plurality of formed elements, and a plurality of undesirable particles, into an inlet of a microfluidic separation channel defined in a thermoplastic;
selecting a wavelength of a standing acoustic wave such that a predetermined width of the microfluidic separation channel is between 30% and 45% of the wavelength of the standing acoustic wave; and
applying the standing acoustic wave transverse to a direction of flow of the whole blood through the microfluidic separation channel such that the plurality of formed elements aggregate toward the axial center of the microfluidic separation channel.