US 12,447,147 B2
Methods of treating, ameliorating, and/or preventing cancer using pyrvinium compositions
Jonathan R. Brody, Philadelphia, PA (US); and Christopher William Schultz, Riverton, NJ (US)
Assigned to Thomas Jefferson University, Philadelphia, PA (US)
Appl. No. 17/770,515
Filed by Thomas Jefferson University, Philadelphia, PA (US)
PCT Filed Oct. 21, 2020, PCT No. PCT/US2020/056641
§ 371(c)(1), (2) Date Apr. 20, 2022,
PCT Pub. No. WO2021/081081, PCT Pub. Date Apr. 29, 2021.
Claims priority of provisional application 62/924,495, filed on Oct. 22, 2019.
Prior Publication US 2022/0409611 A1, Dec. 29, 2022
Int. Cl. A61K 31/4725 (2006.01); A61K 47/14 (2017.01); A61K 47/44 (2017.01); A61P 35/00 (2006.01)
CPC A61K 31/4725 (2013.01) [A61K 47/14 (2013.01); A61K 47/44 (2013.01); A61P 35/00 (2018.01)] 20 Claims
 
1. A composition comprising:
about 0.01 to 5% w/v of a pyrvinium salt;
about 5 to 20% v/v of a polar solvent;
about 0 to 15% v/v of a nonionic emulsifier; and
about 60 to 90% v/v of an aqueous vehicle,
wherein the composition is a solution.