	US 12,447,142 B2
	Compositions and methods for preventing and treating radiation-induced bystander effects caused by radiation or radiotherapy
Ding Xue, Louisville, CO (US); Yu Peng, Bejing (CN); Man Zhang, Beijing (CN); Lingjun Zheng, Boulder, CO (US); Qian Liang, Beijing (CN); Hanzeng Li, Louisville, CO (US); Jau-Song Yu, Taoyuan (TW); and Jeng-Ting Chen, Taoyuan (TW)
Assigned to The Regents of the University of Colorado, Denver, CO (US)
Filed by The Regents of the University of Colorado, Denver, CO (US)
Filed on Jun. 29, 2022, as Appl. No. 17/852,475.
Application 17/852,475 is a continuation of application No. 16/632,046, granted, now 11,452,709, previously published as PCT/US2018/042569, filed on Jul. 17, 2018.
Claims priority of provisional application 62/533,272, filed on Jul. 17, 2017.
Prior Publication US 2023/0233517 A1, Jul. 27, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/353 (2006.01); A61K 31/336 (2006.01); A61K 31/4025 (2006.01); A61K 31/7048 (2006.01)

CPC A61K 31/353 (2013.01) [A61K 31/336 (2013.01); A61K 31/4025 (2013.01); A61K 31/7048 (2013.01)]

7 Claims

1. A method for ameliorating radiation-induced bystander effects (RIBE) in non-irradiated cells of a subject caused by exposure to radiation, comprising administering to the subject a therapeutically effective amount of an agent that inhibits the protease activity of protein Cathepsin B (CTSB), wherein the agent is selected from: quercetin, isoquercetin, E64, CA074 and CA074Me.