US 12,447,122 B2
Silk-based moisturizer compositions and methods thereof
Gregory H. Altman, Providence, RI (US); Dylan S. Haas, Yorktown Heights, NY (US); and Kevin T. Healy, Dedham, MA (US)
Assigned to EVOLVED BY NATURE, INC., Needham, MA (US)
Filed by Evolved By Nature, Inc., Medford, MA (US)
Filed on Jun. 16, 2023, as Appl. No. 18/336,431.
Application 18/336,431 is a continuation of application No. 15/570,653, granted, now 11,878,070, previously published as PCT/US2016/030232, filed on Apr. 29, 2016.
Claims priority of provisional application 62/154,581, filed on Apr. 29, 2015.
Prior Publication US 2024/0189204 A1, Jun. 13, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 8/64 (2006.01); A61G 5/02 (2006.01); A61K 8/04 (2006.01); A61K 8/06 (2006.01); A61K 8/19 (2006.01); A61K 8/20 (2006.01); A61K 8/27 (2006.01); A61K 8/29 (2006.01); A61K 8/36 (2006.01); A61K 8/365 (2006.01); A61K 8/368 (2006.01); A61K 8/37 (2006.01); A61K 8/49 (2006.01); A61K 8/67 (2006.01); A61K 8/73 (2006.01); A61K 8/92 (2006.01); A61K 8/9789 (2017.01); A61Q 1/04 (2006.01); A61Q 5/02 (2006.01); A61Q 5/12 (2006.01); A61Q 15/00 (2006.01); A61Q 17/04 (2006.01); A61Q 19/00 (2006.01); A61Q 19/02 (2006.01); A61Q 19/08 (2006.01); A61Q 19/10 (2006.01); A61Q 1/06 (2006.01)
CPC A61K 8/64 (2013.01) [A61K 8/042 (2013.01); A61K 8/062 (2013.01); A61K 8/064 (2013.01); A61K 8/19 (2013.01); A61K 8/20 (2013.01); A61K 8/27 (2013.01); A61K 8/29 (2013.01); A61K 8/361 (2013.01); A61K 8/365 (2013.01); A61K 8/368 (2013.01); A61K 8/37 (2013.01); A61K 8/4953 (2013.01); A61K 8/676 (2013.01); A61K 8/678 (2013.01); A61K 8/735 (2013.01); A61K 8/922 (2013.01); A61K 8/9789 (2017.08); A61Q 1/04 (2013.01); A61Q 5/02 (2013.01); A61Q 5/12 (2013.01); A61Q 15/00 (2013.01); A61Q 17/04 (2013.01); A61Q 19/00 (2013.01); A61Q 19/007 (2013.01); A61Q 19/02 (2013.01); A61Q 19/08 (2013.01); A61Q 19/10 (2013.01); A61K 2800/10 (2013.01); A61K 2800/28 (2013.01); A61K 2800/30 (2013.01); A61K 2800/805 (2013.01); A61Q 1/06 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A stable emulsion composition comprising:
about 0.001% to about 30% (w/v) of silk fibroin protein fragments having an average weight average molecular weight selected from between about 5 kDa to about 80 kDa and a polydispersity of between about 1.0 and about 5.0;
about 0.1% to about 25% (v/v) of an oil; and
about 99% to about 65% (v/v) water;
wherein the pH of the composition is in the range of about 1.0 to about 8.0,
wherein the silk fibroin protein fragments do not spontaneously or gradually gelate and do not visibly change in color or turbidity when in an aqueous solution for at least four weeks at room temperature.