US 12,447,117 B2
Composition and method of enhancing skin barrier using the same
Eun Jeong Choi, Yongin-si (KR); Hyoung June Kim, Yongin-si (KR); Tae Ryong Lee, Yongin-si (KR); and Hyunjung Choi, Yongin-si (KR)
Assigned to AMOREPACIFIC CORPORATION, Seoul (KR)
Appl. No. 17/288,109
Filed by AMOREPACIFIC CORPORATION, Seoul (KR)
PCT Filed Oct. 23, 2019, PCT No. PCT/KR2019/013920
§ 371(c)(1), (2) Date Apr. 23, 2021,
PCT Pub. No. WO2020/085776, PCT Pub. Date Apr. 30, 2020.
Claims priority of application No. 10-2018-0127637 (KR), filed on Oct. 24, 2018.
Prior Publication US 2021/0378929 A1, Dec. 9, 2021
Int. Cl. A61K 8/365 (2006.01); A61Q 17/00 (2006.01); A61Q 19/00 (2006.01)
CPC A61K 8/365 (2013.01) [A61Q 17/00 (2013.01); A61Q 19/004 (2013.01); A61Q 19/007 (2013.01)] 5 Claims
 
1. A method of enhancing a skin barrier in a subject, comprising applying an effective amount of a composition topically to skin of the subject,
wherein, the composition comprises a compound of Chemical Formula 1 as an active ingredient:

OG Complex Work Unit Chemistry
wherein, in Chemical Formula 1,
R1 to R4 are each independently a hydrogen atom, a hydroxy group, or a carboxyl group, provided that at least one of R1 to R4 is a hydroxy group and at least one of R1 to R4 is a carboxyl group,
wherein the skin of the subject has skin barrier damage caused by ultraviolet rays,
wherein the damaged skin barrier of the subject has a decreased expression of KRT10 (keratin 10) gene and DSC1 (desmocollin-1) gene compared to skin that has not been exposed to UVB and the application of the composition increases the expression of KRT10 gene and DSC1 gene, and
wherein the compound of Chemical Formula 1 is included in a concentration range of 0.01 pM to 10 nM.