US 12,447,002 B2
Distal protection device and manufacturing method therefor
Xiangyu Xu, Suzhou (CN); Shuang Li, Suzhou (CN); Liyou Guo, Suzhou (CN); and Jie Xia, Suzhou (CN)
Assigned to SUZHOU ZENITH VASCULAR SCITECH LIMITED, Jiangsu (CN)
Appl. No. 18/994,905
Filed by SUZHOU ZENITH VASCULAR SCITECH LIMITED, Suzhou (CN)
PCT Filed Jun. 7, 2024, PCT No. PCT/CN2024/101829
§ 371(c)(1), (2) Date Jan. 15, 2025,
PCT Pub. No. WO2024/230853, PCT Pub. Date Nov. 14, 2024.
Claims priority of application No. 202310502337.1 (CN), filed on May 6, 2023.
Prior Publication US 2025/0262042 A1, Aug. 21, 2025
Int. Cl. A61F 2/01 (2006.01)
CPC A61F 2/0105 (2020.05) [A61F 2/011 (2020.05); A61F 2230/0093 (2013.01); A61F 2240/002 (2013.01); A61F 2250/0067 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A distal protector, comprising:
a delivery guidewire assembly (10), comprising a delivery guidewire (1) and a check ring (5);
an umbrella filter assembly (2), wherein the umbrella filter assembly (2) comprises an umbrella skeleton (21), a filter membrane (22) and a fixed ring (4), the delivery guidewire assembly (10) is capable of detachably passing through the umbrella filter assembly (2), a proximal end of the umbrella skeleton (21) is trumpet-shaped, the filter membrane (22) covers the umbrella skeleton (21), and a distal portion of the filter membrane (22) fitting the umbrella skeleton (21) is provided with filter holes; and
a coating assembly (3), wherein the coating assembly (3) is disposed at a distal end of the umbrella filter assembly (2) and comprises a carrier (31) and a thrombolytic drug (32) carried in the carrier (31), wherein the thrombolytic drug (32) is capable of being sustainably released from the carrier (31) at a certain rate,
wherein the carrier (31) comprises a metal-oxide layer (311), the metal-oxide layer (311) is disposed on a surface of the distal end of the umbrella filter assembly (2) and provided with a plurality of receiving holes (3111) communicating with external environment, and the plurality of receiving holes (3111) are configured to receive the thrombolytic drug (32);
wherein the carrier (31) further comprises a hydrogel layer (312), and the hydrogel layer (312) is disposed on one side of the metal-oxide layer (311) facing away from the umbrella filter assembly (2) and capable of sealing the plurality of receiving holes (3111);
wherein the umbrella skeleton (21) comprises a collar (211), a first skeleton main body (212) and a second skeleton main body (213) that are sequentially sleeved on the delivery guidewire (1), the filter membrane (22) covers the first skeleton main body (212), the second skeleton main body (213) forms an opening, and the coating assembly (3) is disposed on the collar (211);
wherein the first skeleton main body (212) is woven mesh-shaped and comprises a first fitting portion (2121) and a connection portion (2123), the first fitting portion (2121) is trumpet-shaped and capable of fitting an internal wall of a blood vessel, a large end of the first fitting portion (2121) faces the second skeleton main body (213), a small end of the first fitting portion (2121) faces the connection portion (2123), the connection portion (2123) is connected to the collar (211), and two ends of the second skeleton main body (213) are connected to the first fitting portion (2121) and the fixed ring (4) respectively; and
wherein the first skeleton main body (212) further comprises a second fitting portion (2122), and the second fitting portion (2122) is connected between the first fitting portion (2121) and the connection portion (2123).