US 12,446,970 B2
Functional ultrasound imaging for spinal cord stimulation electrode guidance and stimulation parameter optimization
Riazul Islam, Rochester, MN (US); Igor A. Lavrov, Rochester, MN (US); Shigao Chen, Rochester, MN (US); and Pengfei Song, Champaign, IL (US)
Assigned to Mayo Foundation for Medical Education and Research, Rochester, MN (US)
Appl. No. 17/763,391
Filed by Mayo Foundation for Medical Education and Research, Rochester, MN (US)
PCT Filed Sep. 28, 2020, PCT No. PCT/US2020/053140
§ 371(c)(1), (2) Date Mar. 24, 2022,
PCT Pub. No. WO2021/062396, PCT Pub. Date Apr. 1, 2021.
Claims priority of provisional application 62/906,336, filed on Sep. 26, 2019.
Prior Publication US 2022/0354589 A1, Nov. 10, 2022
Int. Cl. A61B 8/06 (2006.01); A61B 8/00 (2006.01); A61B 34/20 (2016.01); A61N 1/05 (2006.01); G01S 15/89 (2006.01); G06T 5/70 (2024.01); G06T 7/00 (2017.01); G06T 7/20 (2017.01)
CPC A61B 34/20 (2016.02) [A61B 8/06 (2013.01); A61B 8/469 (2013.01); A61B 8/488 (2013.01); A61B 8/5207 (2013.01); A61B 8/5223 (2013.01); A61B 8/5276 (2013.01); G01S 15/8915 (2013.01); G06T 5/70 (2024.01); G06T 7/0012 (2013.01); G06T 7/20 (2013.01); A61B 2034/2063 (2016.02); A61N 1/0551 (2013.01); G06T 2207/10132 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A method for updating electrical stimulation parameters based on data acquired with an ultrasound system, the method comprising:
(a) accessing ultrasound data with a computer system, the ultrasound data having been acquired with an ultrasound system from a region-of-interest containing a spinal cord of a subject while electrical stimulation was applied to the spinal cord by an electrode;
(b) generating from the ultrasound data, hemodynamic response data indicative of a hemodynamic response in the spinal cord of the subject, wherein the hemodynamic response data comprise measurements of a spinal cord blood volume change in response to the electrical stimulation applied to the spinal cord;
(c) generating updated stimulation parameters using the hemodynamic response data, the updated stimulation parameters indicating settings for a spinal cord stimulation system for delivering electrical stimulation to the spinal cord of the subject; and
(d) generating and delivering the electrical stimulation to the spinal cord of the subject using the electrode of the spinal cord stimulation system by applying the updated stimulation parameters to a pulse generator of the spinal cord stimulation system to generate a stimulation signal that is applied to the electrode in order to cause the electrode to generate the electrical stimulation.