US 12,446,933 B2
Ultrathin films for triclosan transfer to metal medical devices
Charles Florek, Downingtown, PA (US); and David A. Armbruster, West Chester, PA (US)
Assigned to DePuy Synthes Products, Inc., Raynham, MA (US)
Filed by DePuy Synthes Products, Inc., Raynham, MA (US)
Filed on May 24, 2022, as Appl. No. 17/664,676.
Claims priority of provisional application 63/192,339, filed on May 24, 2021.
Prior Publication US 2022/0370692 A1, Nov. 24, 2022
Int. Cl. A61B 17/80 (2006.01); A61K 31/09 (2006.01); A61L 27/54 (2006.01); A61L 31/02 (2006.01); A61L 31/10 (2006.01); A61L 31/14 (2006.01); A61L 31/16 (2006.01); B05D 1/18 (2006.01)
CPC A61B 17/8052 (2013.01) [A61K 31/09 (2013.01); A61L 27/54 (2013.01); A61L 31/022 (2013.01); A61L 31/10 (2013.01); A61L 31/148 (2013.01); A61L 31/16 (2013.01); B05D 1/18 (2013.01); A61L 2300/202 (2013.01); A61L 2300/216 (2013.01); A61L 2300/404 (2013.01); A61L 2420/02 (2013.01); A61L 2420/06 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A system for reducing microbial infection at an orthopedic implant surgical site comprising:
an orthopedic implant body defining an outer implant surface, the orthopedic implant body further defining one or more apertures extending from the outer surface through the implant body and configured to receive a bone fastener;
a bone fastener configured to be disposed within the one or more apertures so as to secure the orthopedic implant body to a bone, the bone fastener defining an outer fastener surface;
a biodegradable polymer thin film disposed within at least one of the one or more apertures or the corresponding outer fastener surface; and,
a vaporizable antimicrobial agent disposed within the biodegradable polymer thin film,
wherein
the biodegradable polymer thin film has a surface area coat weight of about 50-250 μg/cm2,
the vaporizable antimicrobial agent has a surface area concentration of about 5-85 μg/cm2,
the antimicrobial agent has a surface area concentration that is sufficient to produce an effective zone of inhibition of at least 0.5 mm from a periphery of the outer implant surface,
and,
a torque required for releasing the fastener from a corresponding aperture of the orthopedic implant body following use of an insertion torque that is suitable for implantation of the orthopedic implant body in a subject is not less than about 90% of a torque required for releasing an uncoated and otherwise identical fastener from a corresponding aperture of an uncoated but otherwise identical orthopedic implant body for up to 5 days following implantation of the orthopedic implant body in the subject.