| CPC A61B 17/22 (2013.01) [A61F 2/013 (2013.01); A61M 25/0075 (2013.01); A61B 2017/00022 (2013.01); A61B 2017/00154 (2013.01); A61B 2017/22079 (2013.01); A61B 2017/22082 (2013.01); A61B 2217/007 (2013.01); A61F 2/011 (2020.05)] | 17 Claims |

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1. An aspiration thrombectomy system, comprising:
a catheter system including an aspiration catheter having a proximal portion, a distal end and a lumen extending through the aspiration catheter;
a vacuum source fluidically coupled to the catheter system;
a vacuum valve connected between the vacuum source and the proximal portion of the aspiration catheter to control a vacuum flow in the catheter lumen;
a vent valve fluidically coupled to the proximal portion of the aspiration catheter, the vent valve being configured to control a flow of a vent fluid in the catheter lumen;
and
a controller configured to open and close the vacuum valve and the vent valve in at least a first predetermined sequence comprising a vacuum-only state in which the vacuum valve is open and the vent valve is closed, a first off-off state following the vacuum-only state in which both the vacuum valve and the vent valve are closed, a vent-only state in which the vent valve is open and the vacuum valve is closed, and a second off-off state after the vent- only state in which both the vacuum valve and the vent valve are closed, wherein-
(a) the first off-off state lasts a predetermined period of time from 5.2 ms to less than the time for a pressure pulse to propagate from the vacuum valve to the distal end of the catheter,
(b) the second off-off state lasts a predetermined period of time, and
(c) the first predetermined sequence is repeated at a first frequency of approximately 6 Hz to approximately 16 Hz.
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