US 12,446,879 B1
Magnetic hydrogel, preparation method thereof and non-invasive skin mechanical loading device
Huicong Du, Xi'an (CN); Renjianzhi Zhang, Xi'an (CN); Maoguo Shu, Xi'an (CN); and Juan Wu, Xi'an (CN)
Filed by The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an (CN)
Filed on Apr. 24, 2025, as Appl. No. 19/189,216.
Claims priority of application No. 202510058579.5 (CN), filed on Jan. 15, 2025.
Int. Cl. A61B 17/08 (2006.01); A61B 17/00 (2006.01); A61L 26/00 (2006.01); C08L 5/04 (2006.01); C08L 89/06 (2006.01)
CPC A61B 17/085 (2013.01) [A61L 26/0052 (2013.01); A61L 26/008 (2013.01); C08L 5/04 (2013.01); C08L 89/06 (2013.01); A61B 2017/00876 (2013.01)] 5 Claims
OG exemplary drawing
 
1. A non-invasive skin mechanical loading device, comprising:
at least one pair of magnetized magnetic hydrogels of GA-Al@NdFeB, wherein magnetic poles of the at least one pair of magnetized magnetic hydrogels of GA-Al@NdFeB are opposite, the at least one pair of magnetized magnetic hydrogels of GA-Al@NdFeB are configured to be applied symmetrically on two sides of a skin wound, respectively, and are configured to be closely attached to edges of the two sides of the skin wound; and
driving magnets, wherein the driving magnets correspond to the at least one pair of magnetized magnetic hydrogels of GA-Al@NdFeB in a one-to-one manner, and each of the driving magnets is arranged on a side of corresponding one of the at least one pair of magnetized magnetic hydrogels of GA-Al@NdFEB far away from the skin wound; the driving magnets are configured to oppositely push the skin wound from the two sides of the skin wound; magnetic poles of the driving magnets are the same as the magnetic poles of the at least one pair of magnetized magnetic hydrogels of GA-Al@NdFeB, respectively, thereby generating repulsive forces between the driving magnets and the at least one pair of magnetized magnetic hydrogels of GA-Al@NdFeB, and the at least one pair of magnetized magnetic hydrogels of GA-Al@NdFEB are configured to be pushed by the repulsive forces to achieve a traction wound contraction;
wherein a preparation method of each magnetized magnetic hydrogel of GA-Al@NdFeB comprises:
mixing a gelatin solution, a sodium alginate solution, deionized water, and neodymium iron boron (NdFeB) particles thoroughly to obtain a reaction precursor A solution;
mixing calcium carbonate, gluconolactone, transglutaminase, and deionized water thoroughly to obtain a reaction precursor B solution; and
adding the reaction precursor solution A into the reaction precursor solution B, then stirring thoroughly and mixing to obtain a mixture, followed by sealing the mixture to place in a constant-temperature environment to obtain a magnetic hydrogel of GA-Al@NdFeB; magnetizing the magnetic hydrogel of GA-Al@NdFeB, thereby endowing the NdFEB particles embedded within the magnetic hydrogel of GA-Al@NdFeB with magnetic polarity to obtain the magnetized magnetic hydrogel of GA-Al@NdFeB.