| CPC A61B 6/504 (2013.01) [A61B 6/032 (2013.01); A61B 6/481 (2013.01); A61B 6/542 (2013.01); A61M 5/007 (2013.01)] | 4 Claims |

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1. A system, comprising:
an x-ray source that emits a beam of x-rays toward a subject to be imaged;
a detector that receives the x-rays attenuated by the subject;
a data acquisition system (DAS) operably connected to the detector; and
a computer operably connected to the DAS and configured with instructions in non-transitory memory that when executed cause the computer to:
process projection data of a monitoring region of interest (ROI) of the subject from the DAS to measure a contrast signal of a contrast agent injected into the subject;
determine a hemodynamic marker of the subject based on the contrast signal, the hemodynamic marker used to approximate a duration between an arterial peak of the contrast agent at the monitoring ROI and a venous return to baseline of the contrast agent at the monitoring ROI;
generate a scan prescription for a multi-phase contrast scan of the subject based on the hemodynamic marker of the subject; and
perform the multi-phase contrast scan according to the scan prescription.
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