US 12,446,821 B2
Muscle relaxation monitoring apparatus and calibration processing method
Hiroshi Yoshihara, Tokorozawa (JP); Shigeyoshi Kitamura, Tokorozawa (JP); Kazuya Nagase, Tokorozawa (JP); Shunji Iwata, Tokorozawa (JP); and Shunichi Takagi, Tokyo (JP)
Assigned to NIHON KOHDEN CORPORATION, Tokyo (JP); and Shunichi TAKAGI, Tokyo (JP)
Appl. No. 17/773,451
Filed by NIHON KOHDEN CORPORATION, Tokyo (JP); and Shunichi Takagi, Tokyo (JP)
PCT Filed Oct. 23, 2020, PCT No. PCT/JP2020/039952
§ 371(c)(1), (2) Date Apr. 29, 2022,
PCT Pub. No. WO2021/085337, PCT Pub. Date May 6, 2021.
Claims priority of application No. 2019-198592 (JP), filed on Oct. 31, 2019.
Prior Publication US 2022/0401008 A1, Dec. 22, 2022
Int. Cl. A61B 5/00 (2006.01); A61B 5/395 (2021.01)
CPC A61B 5/395 (2021.01) [A61B 5/4821 (2013.01); A61B 2560/0223 (2013.01)] 5 Claims
OG exemplary drawing
 
1. A muscle relaxation monitoring apparatus comprising:
a controller;
a stimulation generator configured to generate an electrical stimulation signal to be applied to a nerve of a subject;
a response detector configured to detect a stimulation response of a muscle of the subject to the electrical stimulation; and
a calibration processing section controlled by the controller, the calibration processing section being configured to perform a calibration that:
directs the stimulation generator to apply a predetermined stimulation current value at a predetermined stimulation timing to the nerve; and
acquires, from the response detector, a stimulation current value of a supramaximal stimulation exceeding a maximal stimulation of the subject, based on an amplitude peak value of an electric signal corresponding to the stimulation response of the muscle,
wherein the stimulation response is used with the stimulation current value to determine muscle's relaxation state for administration of a muscle relaxant agent or a muscle relaxation recovery agent;
wherein the calibration is based on a first preset stimulation timing when the subject is in an awake state, and
the calibration is based on a second preset stimulation timing that is longer than the first preset stimulation timing when the subject is in a muscle relaxation state.