	US 12,446,607 B2
	Probiotic microcapsule and preparation method thereof
Mingfei Yao, Zhejiang (CN); Shengyi Han, Zhejiang (CN); Xin Jin, Zhejiang (CN); Weixin Huang, Zhejiang (CN); Jiaojiao Xie, Zhejiang (CN); Yanmeng Lu, Zhejiang (CN); Bona Wang, Zhejiang (CN); Ling Gao, Zhejiang (CN); Chihui Yu, Zhejiang (CN); and Lanjuan Li, Zhejiang (CN)
Assigned to Shaoxing Tongchuang Biotechnology Co., Ltd., Shaoxing (CN)
Appl. No. 17/762,078
Filed by Shaoxing Tongchuang Biotechnology Co., Ltd., Zhejiang (CN)
PCT Filed May 31, 2021, PCT No. PCT/CN2021/097408 § 371(c)(1), (2) Date Aug. 4, 2022, PCT Pub. No. WO2022/160540, PCT Pub. Date Aug. 4, 2022.
Claims priority of application No. 202110138512.4 (CN), filed on Feb. 1, 2021.
Prior Publication US 2024/0108047 A1, Apr. 4, 2024
Int. Cl. A23L 33/135 (2016.01); A23L 29/212 (2016.01); A23L 29/262 (2016.01); A23L 29/275 (2016.01); A23P 10/30 (2016.01); A61K 9/48 (2006.01); A61K 9/50 (2006.01); A61K 35/00 (2006.01); A61K 35/747 (2015.01)

CPC A23L 33/135 (2016.08) [A23L 29/212 (2016.08); A23L 29/262 (2016.08); A23L 29/275 (2016.08); A23P 10/30 (2016.08); A61K 9/4808 (2013.01); A61K 9/4866 (2013.01); A61K 9/5036 (2013.01); A61K 9/5089 (2013.01); A61K 35/747 (2013.01); A23V 2400/181 (2023.08); A61K 2035/115 (2013.01)]

9 Claims

1. A preparation method of probiotic microcapsules, comprising the following steps:

(a) preparing a capsule core containing probiotics: mixing capsule core materials including probiotic powder, microcrystalline cellulose and starch, adding a hydroxypropyl methylcellulose solution, making the obtained mixture materials into spherical particulate capsule cores by an extrusion spherization method;

(b) coating by atomization: coating the capsule core with a coating material solution in a single layer or multiple layers by atomization, obtaining core-shell microcapsules, wherein in step (b):

atomization pressure of 0.1-0.5 mpa is applied, wherein a wind speed at an air inlet is 20-25 m³/h, wherein a wind speed at an air outlet is 20-25 m³/h, wherein temperature is 23-27° C., and wherein a flow rate of the coating material solution is 0.3 mL/min-0.6 mL/min.