US 12,446,572 B2
Cross-circulation platform for recovery, regeneration, and maintenance of extracorporeal organs
Matthew Bacchetta, Tenafly, NJ (US); Scott Chicotka, New York, NY (US); Kenmond Fung, New York, NY (US); Brandon Guenthart, New York, NY (US); John O'Neill, New York, NY (US); and Gordana Vunjak-Novakovic, New York, NY (US)
Assigned to The Trustees of Columbia University in the City of New York, New York, NY (US)
Filed by The Trustees of Columbia University in the City of New York, New York, NY (US)
Filed on Mar. 25, 2024, as Appl. No. 18/615,506.
Application 18/615,506 is a continuation of application No. 16/244,283, filed on Jan. 10, 2019, granted, now 11,968,974.
Application 16/244,283 is a continuation of application No. PCT/US2017/041990, filed on Jul. 13, 2017.
Claims priority of provisional application 62/472,744, filed on Mar. 17, 2017.
Claims priority of provisional application 62/361,843, filed on Jul. 13, 2016.
Prior Publication US 2024/0224990 A1, Jul. 11, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A01N 1/00 (2006.01); A01N 1/10 (2025.01); A01N 1/122 (2025.01); A01N 1/143 (2025.01); A61J 1/00 (2023.01); A61M 1/16 (2006.01); C12M 1/00 (2006.01); C12M 1/34 (2006.01); A01N 1/16 (2025.01); A61M 1/36 (2006.01); A61M 1/38 (2006.01)
CPC A01N 1/122 (2025.01) [A01N 1/10 (2025.01); A01N 1/143 (2025.01); A61J 1/00 (2013.01); A61M 1/16 (2013.01); C12M 29/12 (2013.01); C12M 29/14 (2013.01); C12M 41/16 (2013.01); A01N 1/16 (2025.01); A61M 1/3621 (2013.01); A61M 1/38 (2013.01); A61M 2210/1039 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A system for physiologic regulation of an extracorporeal organ, tissue or bioengineered graft via cross-circulation with a host organism, comprising
an extracorporeal organ chamber for containing and supporting the extracorporeal organ, tissue or bioengineered graft, wherein the chamber comprises a time- and temperature-controlled humidifier that directs a misting spray onto the organ, tissue or bioengineered graft and into the chamber to maintain a humid environment within the chamber; and
an extracorporeal cross-circulation circuit for connecting the extracorporeal organ, tissue or bioengineered graft with a host organism for cross-circulation of blood or plasma, which circuit comprises:
fluid conduits providing flow of the blood or plasma between a vascular system of the host organism to vasculature of the extracorporeal organ, tissue or bioengineered graft;
wherein a first fluid conduit for connecting the host organism to the extracorporeal organ comprises thereon a circulating pump which pumps blood through a circuit which splits to return blood cells directly back to a blood vessel of the host organism and plasma to the extracorporeal organ, and wherein the first fluid conduit comprises an oxygenator.