US 12,117,435 B2
Portable electrochemical-sensor system for analyzing user health conditions and method thereof
Raman Koul, Calgary (CA); Razieh Salahandish, Calgary (CA); Gang Wang, Calgary (CA); Sumrita Bhat, Calgary (CA); Nikhil Suresh Vastarey, Calgary (CA); and Anmol Singh Kapoor, Calgary (CA)
Assigned to CARDIAI TECHNOLOGIES LTD., Calgary (CA)
Appl. No. 17/261,476
Filed by Cardiai Technologies Ltd., Calgary (CA)
PCT Filed Nov. 4, 2019, PCT No. PCT/CA2019/051567
§ 371(c)(1), (2) Date Jan. 19, 2021,
PCT Pub. No. WO2020/087187, PCT Pub. Date May 7, 2020.
Claims priority of provisional application 62/755,148, filed on Nov. 2, 2018.
Claims priority of provisional application 62/786,180, filed on Dec. 28, 2018.
Claims priority of provisional application 62/875,131, filed on Jul. 17, 2019.
Prior Publication US 2021/0270766 A1, Sep. 2, 2021
Int. Cl. G01N 33/487 (2006.01); G01N 27/327 (2006.01); G06V 10/22 (2022.01); G16H 40/20 (2018.01); G16H 40/67 (2018.01); G16H 50/20 (2018.01)
CPC G01N 33/48785 (2013.01) [G01N 27/3278 (2013.01); G16H 40/20 (2018.01); G16H 40/67 (2018.01); G16H 50/20 (2018.01); G06V 10/225 (2022.01)] 22 Claims
OG exemplary drawing
 
1. An apparatus for analyzing a bodily fluid sample of a user, the apparatus comprising:
a housing comprising at least one first port for receiving an electrochemical-sensor structure, the electrochemical-sensor structure comprising a first circuitry having a first set of electrodes for contacting the bodily fluid sample;
an identification circuitry for detecting predefined information stored with any of the electrochemical-sensor structure and a component associated with the electrochemical-sensor structure, the predefined information indicative of one or more biomarkers analyzable using the electrochemical-sensor structure;
an analysis circuitry comprising a set of coupling electrodes for electrically coupling to the first set of electrodes of the electrochemical-sensor structure for analyzing the identified one or more biomarkers in the bodily fluid sample;
a control circuitry coupled to the identification and analysis circuitries for determining a set of bio-sensing parameters based on the identified one or more biomarkers and for controlling the analysis circuitry to analyze the identified one or more biomarkers in the bodily fluid sample based on the set of bio-sensing parameters; and
an output for outputting an analytical result of said analysis of the identified one or more biomarkers in the bodily fluid sample;
wherein the set of coupling electrodes comprise at least a coupling reference electrode (RE), a coupling control electrode (CE), and a plurality of coupling working electrodes (Wes) for electrically coupling to a RE, a CE, and a plurality of WEs of the electrochemical-sensor structure;
wherein a first set of at least one of the coupling WEs are for electrically coupling to a first set of WEs of the electrochemical-sensor structure oversaturated with a first set of one or more capture ligands;
wherein a second set of at least one of the coupling WEs are for electrically coupling to a second set of WEs of the electrochemical-sensor structure cross-linked with predefined concentration of a second set of one or more capture ligands; and
wherein the analysis circuitry is for analyzing the identified one or more biomarkers in the bodily fluid sample by calculating analyte concentration based on the difference of the charge transfer resistances (RCTs) between the first and second sets of WEs of the electrochemical-sensor structure.