US 12,117,427 B2
LC/MS adduct mitigation by vapor deposition coated surfaces
Kerri M. Smith, Marlborough, MA (US); and Paul Rainville, Princeton, MA (US)
Assigned to Waters Technologies Corporation, Milford, MA (US)
Filed by Waters Technologies Corporation, Milford, MA (US)
Filed on Jun. 29, 2023, as Appl. No. 18/216,064.
Application 18/216,064 is a continuation of application No. 17/150,802, filed on Jan. 15, 2021, granted, now 11,740,211.
Claims priority of provisional application 63/071,643, filed on Aug. 28, 2020.
Claims priority of provisional application 62/968,639, filed on Jan. 31, 2020.
Prior Publication US 2023/0408461 A1, Dec. 21, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 30/72 (2006.01); C23C 14/04 (2006.01); C23C 14/12 (2006.01); C23C 14/46 (2006.01); G01N 30/02 (2006.01)
CPC G01N 30/72 (2013.01) [C23C 14/046 (2013.01); C23C 14/12 (2013.01); G01N 2030/027 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A method of separating and analyzing critical pairs in a sample comprising:
injecting the sample into a chromatographic system having a fluid-contacting coating on a metallic surface defining a sample flow path, wherein the coating comprises an alkylsilyl coating made using vapors of bis(trichlorosilyl)ethane or bis(trimethoxysilyl)ethane, and the sample comprises two or more structural isomers defining the critical pairs;
flowing the injected sample through the chromatographic system along the sample flow path;
separating the flowing sample with the chromatographic system; and
analyzing separated critical pairs with a mass spectrometer.