US 12,116,597 B2
Autophagy as a therapeutic target for intracranial aneurysm
Dong H. Kim, Houston, TX (US); Yanning Rui, Houston, TX (US); Zhen Xu, Houston, TX (US); and John Hagan, Houston, TX (US)
Assigned to THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Filed by THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Filed on May 25, 2022, as Appl. No. 17/824,621.
Claims priority of provisional application 63/296,825, filed on Jan. 5, 2022.
Claims priority of provisional application 63/296,817, filed on Jan. 5, 2022.
Claims priority of provisional application 63/296,821, filed on Jan. 5, 2022.
Claims priority of provisional application 63/296,820, filed on Jan. 5, 2022.
Prior Publication US 2023/0270715 A1, Aug. 31, 2023
Int. Cl. C12N 5/071 (2010.01); A61B 17/12 (2006.01); A61K 31/351 (2006.01); A61K 31/37 (2006.01); A61K 31/404 (2006.01); A61K 31/4706 (2006.01); A61K 31/496 (2006.01); A61K 31/5025 (2006.01); A61K 31/506 (2006.01); A61K 31/517 (2006.01); A61K 31/52 (2006.01); A61K 31/5377 (2006.01); A61K 31/55 (2006.01); A61K 38/10 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); C07K 14/495 (2006.01)
CPC C12N 5/069 (2013.01) [A61B 17/1215 (2013.01); A61K 31/351 (2013.01); A61K 31/37 (2013.01); A61K 31/404 (2013.01); A61K 31/4706 (2013.01); A61K 31/496 (2013.01); A61K 31/5025 (2013.01); A61K 31/506 (2013.01); A61K 31/517 (2013.01); A61K 31/52 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); A61K 38/10 (2013.01); A61P 9/00 (2018.01); A61P 9/10 (2018.01); C07K 14/495 (2013.01); C12N 2510/02 (2013.01)] 16 Claims
 
1. A method for treating a human subject at risk of suffering from an intracranial aneurysm comprising administering to said human subject a therapeutically effective dose of an autophagy inhibitor, wherein the autophagy inhibitor is selected from the group consisting of wortmannin, chloroquine, clomipramine, 3-Methyladenine, Bafilomycin A1, Pepstatin A, and Pepstatin E-64-d, wherein the human subject carries a variant affecting the expression of a Thrombospondin Type 1 Domain Containing 1 (THSD1) gene.