	US 12,116,461 B2
	Host-guest interactions for pa superstructure formation
Samuel I. Stupp, Chicago, IL (US); Alexandra N. Kolberg, Chicago, IL (US); Tristan D. Clemons, Evanston, IL (US); and Stacey M. Chin, Cambridge, MA (US)
Assigned to Northwestern University, Evanston, IL (US)
Filed by Northwestern University, Evanston, IL (US)
Filed on Aug. 23, 2021, as Appl. No. 17/409,450.
Claims priority of provisional application 63/068,552, filed on Aug. 21, 2020.
Prior Publication US 2022/0056219 A1, Feb. 24, 2022
Int. Cl. C08L 101/00 (2006.01); B33Y 80/00 (2015.01); C08G 83/00 (2006.01); C08J 3/075 (2006.01); C09D 5/02 (2006.01); C12N 5/00 (2006.01); C12N 5/0793 (2010.01); C08L 5/16 (2006.01); C08L 101/14 (2006.01)

CPC C08G 83/008 (2013.01) [B33Y 80/00 (2014.12); C08J 3/075 (2013.01); C08L 101/00 (2013.01); C09D 5/02 (2013.01); C12N 5/00 (2013.01); C12N 5/0619 (2013.01); C08G 2210/00 (2013.01); C08J 2300/204 (2013.01); C08L 5/16 (2013.01); C08L 101/14 (2013.01); C12N 2501/13 (2013.01); C12N 2513/00 (2013.01); C12N 2533/40 (2013.01); C12N 2533/70 (2013.01)]

6 Claims

1. A composition comprising:

a. one or more host peptide amphiphiles comprising a hydrophobic segment comprising an 8-24 carbon alkyl chain (C_8-24), a structural peptide segment comprising V₂A₂, a charged peptide segment comprising E₄, and a host moiety comprising β-cyclodextrin; and

b. one or more guest peptide amphiphiles comprising a hydrophobic segment comprising an 8-24 carbon alkyl chain (C_8-24), a structural peptide segment comprising V₂A₂, a charged peptide segment comprising E₄, and a guest moiety comprising adamantane; and

c. one or more diluent peptide amphiphiles, wherein each of the one or more diluent peptide amphiphiles comprises a hydrophobic segment comprising an 8-24 carbon alkyl chain (C_8-24), a structural peptide segment, and a charged peptide segment, and does not comprise a host moiety or a guest moiety,

wherein the host moiety and the guest moiety interact non-covalently to form a host-guest complex within the composition.