US 12,116,421 B2
Peptide-based Dopa containing adhesive gels
Charlotte A. E. Hauser, Thuwal (SA); Maria Hountondji, Thuwal (SA); Manola Moretti, Thuwal (SA); and Panagiotis Bilalis, Thuwal (SA)
Assigned to KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY, Thuwal (SA)
Appl. No. 18/021,645
Filed by KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY, Thuwal (SA)
PCT Filed Sep. 2, 2021, PCT No. PCT/IB2021/057996
§ 371(c)(1), (2) Date Feb. 16, 2023,
PCT Pub. No. WO2022/049508, PCT Pub. Date Mar. 10, 2022.
Claims priority of provisional application 63/073,505, filed on Sep. 2, 2020.
Prior Publication US 2023/0374069 A1, Nov. 23, 2023
Int. Cl. C07K 7/06 (2006.01); C12N 5/00 (2006.01); C12N 5/07 (2010.01)
CPC C07K 7/06 (2013.01) [C12N 5/0062 (2013.01); C12N 5/0601 (2013.01); C12N 2513/00 (2013.01); C12N 2533/50 (2013.01)] 22 Claims
 
1. An ultrashort peptide comprising a sequence selected from the group consisting of:
 
 (SEQ ID NO: 1)
 
 DopaIIZK,
 
 
 
 (SEQ ID NO: 2)
 
 IIZDopaK,
 
 
 
 (SEQ ID NO: 3)
 
 IIZKDopa,
 
 
 
 (SEQ ID NO: 4)
 
 IIZ(KDopa)2,
 
 and
 
 
 
 (SEQ ID NO: 5)
 
 IIZ(KDopa)3,
wherein I is isoleucine, L is leucine, K is lysine, Z is cyclohexylalanine, and Dopa is levodopa.