US 12,116,417 B2
Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same
Jong Seo Lee, Gyeonggi-do (KR); Kyu Tae Kim, Gyeonggi-do (KR); Young Ha Lee, Seoul (KR); In Sik Hwang, Incheon (KR); and Bong Kook Ko, Seoul (KR)
Assigned to GC Cell Corporation, (KR)
Appl. No. 16/764,276
Filed by GC CELL CORPORATION, Yongin-si (KR)
PCT Filed Nov. 14, 2018, PCT No. PCT/KR2018/013928
§ 371(c)(1), (2) Date Sep. 28, 2020,
PCT Pub. No. WO2019/098682, PCT Pub. Date May 23, 2019.
Claims priority of application No. 10-2017-0151841 (KR), filed on Nov. 14, 2017.
Prior Publication US 2021/0179733 A1, Jun. 17, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/32 (2006.01); A61K 35/17 (2015.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); G01N 33/574 (2006.01)
CPC C07K 16/32 (2013.01) [A61K 35/17 (2013.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 14/70578 (2013.01); G01N 33/574 (2013.01); A61K 38/00 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/5158 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/92 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01)] 24 Claims
OG exemplary drawing
 
1. An antibody against human epidermal growth factor receptor 2 (HER2), or an antigen-binding fragment thereof, comprising:
(a) a heavy chain variable region comprising CDRH1 of SEQ ID NO: 7, CDRH2 of SEQ ID NO: 8 and CDRH3 of SEQ ID NO: 9, and a light chain variable region comprising CDRL1 of SEQ ID NO: 10, CDRL2 of SEQ ID NO: 11 and CDRL3 of SEQ ID NO: 12;
(b) a heavy chain variable region comprising CDRH1 of SEQ ID NO: 7, CDRH2 of SEQ ID NO: 8 and CDRH3 of SEQ ID NO: 71, and a light chain variable region comprising CDRL1 of SEQ ID NO: 10, CDRL2 of SEQ ID NO: 11 and CDRL3 of SEQ ID NO: 12;
(c) a heavy chain variable region comprising CDRH1 of SEQ ID NO: 7, CDRH2 of SEQ ID NO: 8 and CDRH3 of SEQ ID NO: 72, and a light chain variable region comprising CDRL1 of SEQ ID NO: 10, CDRL2 of SEQ ID NO: 11 and CDRL3 of SEQ ID NO: 73; or
(d) a heavy chain variable region comprising CDRH1 of SEQ ID NO: 7, CDRH2 of SEQ ID NO: 8 and CDRH3 of SEQ ID NO: 72, and a light chain variable region comprising CDRL1 of SEQ ID NO: 10, CDRL2 of SEQ ID NO: 11 and CDRL3 of SEQ ID NO: 74.