US 12,115,510 B2
High surface area coatings for solid-phase synthesis
Bichlien Hoang Nguyen, Seattle, WA (US); Karin Strauss, Seattle, WA (US); and Hsing-Yeh Parker, Woodinville, WA (US)
Assigned to MICROSOFT TECHNOLOGY LICENSING, LLC, Redmond, WA (US)
Filed by MICROSOFT TECHNOLOGY LICENSING, LLC, Redmond, WA (US)
Filed on Mar. 15, 2022, as Appl. No. 17/695,734.
Application 17/695,734 is a continuation of application No. 16/597,799, filed on Oct. 9, 2019.
Prior Publication US 2022/0203324 A1, Jun. 30, 2022
Int. Cl. B01J 19/00 (2006.01); C07K 1/04 (2006.01); C25D 5/16 (2006.01); C25D 5/48 (2006.01); C25D 17/10 (2006.01)
CPC B01J 19/0046 (2013.01) [C07K 1/042 (2013.01); C25D 5/16 (2013.01); C25D 5/48 (2013.01); C25D 17/10 (2013.01); B01J 2219/00497 (2013.01); B01J 2219/0059 (2013.01); B01J 2219/00596 (2013.01); B01J 2219/00612 (2013.01); B01J 2219/00722 (2013.01); B01J 2219/00725 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method of making a stack for solid-phase polymer synthesis comprising:
depositing a coating made up of nanoparticles that has a three-dimensional structure to a solid substrate wherein, depositing the coating comprises baking the nanoparticles for at least two hours to form the coating and the coating increases an available surface area relative to the solid substrate, wherein a yield of polymer synthesized on the stack is at least 10 times greater than a yield of solid-phase polymer synthesis on the solid substrate without the coating; and
attaching functional groups to the coating.