	US 12,115,467 B2
	Amine separation method using liquid chromatography
Toru Shibata, Tokyo (JP); Satoshi Shinkura, Tokyo (JP); and Atsushi Ohnishi, Tokyo (JP)
Assigned to Daicel Corporation, Tokyo (JP)
Appl. No. 17/617,059
Filed by DAICEL CORPORATION, Osaka (JP)
PCT Filed Jun. 12, 2020, PCT No. PCT/JP2020/023153 § 371(c)(1), (2) Date Dec. 7, 2021, PCT Pub. No. WO2020/251003, PCT Pub. Date Dec. 17, 2020.
Claims priority of application No. 2019-110811 (JP), filed on Jun. 14, 2019; and application No. 2019-219615 (JP), filed on Dec. 4, 2019.
Prior Publication US 2022/0339555 A1, Oct. 27, 2022
Int. Cl. B01D 15/36 (2006.01); B01D 15/16 (2006.01); B01D 15/32 (2006.01); B01D 15/38 (2006.01); B01J 20/28 (2006.01); B01J 20/286 (2006.01); B01J 20/29 (2006.01); B01J 20/32 (2006.01); B01J 41/20 (2006.01); G01N 30/02 (2006.01)

CPC B01D 15/36 (2013.01) [B01D 15/166 (2013.01); B01D 15/32 (2013.01); B01D 15/38 (2013.01); B01D 15/3833 (2013.01); B01J 20/286 (2013.01); B01J 20/29 (2013.01); B01J 20/3204 (2013.01); B01J 20/321 (2013.01); B01J 20/3212 (2013.01); B01J 20/3219 (2013.01); B01J 20/3255 (2013.01); B01J 41/20 (2013.01); G01N 30/02 (2013.01); G01N 2030/027 (2013.01)]

13 Claims

1. A separation method for amine, the separation method comprising:

performing liquid chromatography,

wherein a separating agent in which a ligand having a crown ether-like cyclic structure is supported on a carrier is used as a stationary phase, and

wherein a mobile phase comprises an aqueous solution of a salt of a hydrophobic organic acid.

8. A separation method for amine, the separation method comprising: performing liquid chromatography,

wherein a separating agent in which a ligand having a crown ether-like cyclic structure is supported on and chemically bound to a carrier is used as a stationary phase,

wherein a mobile phase comprises an aqueous solution of a salt of a chaotropic anion, and

wherein the mobile phase does not contain perchloric acid.