CPC A61K 31/451 (2013.01) [A61K 31/4545 (2013.01); A61P 3/06 (2018.01); C07D 211/14 (2013.01); C07D 401/04 (2013.01)] | 7 Claims |
1. A compound of Formula I:
![]() or a pharmaceutically acceptable salt, prodrug, deuterated analog, stereoisomer, or mixture of stereoisomers thereof,
wherein:
Ring A is a six-membered aromatic ring; X1, X4 and X5 are independently CH or CR1, X2 is CH or CR2, and X3 is CR3, provided that at least one of X2 and X3 is other than CH;
Ring B is a six-membered non-aromatic ring; Z1 is CH2, CHR9, CR9R9, or S; Z2 is N; and Z3 is CHR7 or CR7R9;
each of R1 and R9 are independently C1-C6 alkyl, heterocyclyl, heteroaryl, halo, OH, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, CN, or NH2;
m is 0, 1, 2, 3 or 4, and is not inclusive of R9 groups at Z1 or Z3;
R3 is C3-C6 cycloalkyl, phenyl, heteroaryl, or heterocyclyl;
R2 is H, C1-C6 alkyl, halo, OH, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, CN, NH2, C3-C6 cycloalkyl, phenyl, heteroaryl, or heterocyclyl, wherein each of the C3-C6 cycloalkyl, phenyl, heteroaryl, or heterocyclyl of R2 and R3 is monocyclic and further wherein each of which is optionally substituted with one to five R4;
each R4 is independently selected from C1-C6 alkyl, halo, OH, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, and CN;
R6 is H, halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 haloalkyl, OH, CN, or NH2;
R7 is H, halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 haloalkyl, OH, CN, or NH2;
R8 is C3-C6 alkyl, C1-C6 heteroalkyl, C3-C6 cycloalkyl, heterocyclyl, aryl, heteroaryl, C3-C6 cycloalkyl-C1-C6 alkyl, heteroaryl-C1-C6 alkyl, or heterocyclyl-C1-C6 alkyl; each of which is optionally substituted with one to four substituents independently selected from C1-C6 alkyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 haloalkyl, halo, =NR11, CN, NH2 and OH; or
R8 and R7 together with the atoms to which they are attached form Ring C, which is a C3-C6 cycloalkyl or heterocyclyl ring fused with Ring B, wherein Ring C is optionally substituted with one to four R12;
R11 is H or C1-C6 alkyl;
each R12 is independently selected from the group consisting of C1-C6 alkyl, halo, OH, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 haloalkyl, NH2 and CN; or two R12 together with the atoms to which they are attached form Ring D, which is C3-C6 cycloalkyl or heterocyclyl fused with Ring C; or two R12 on a same carbon atom form=O or =NR11.
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