US 12,115,153 B2
Methods of treating cancer
Wayne Rothbaum, Delray Beach, FL (US)
Assigned to Kartos Therapeutics, Inc., New York, NY (US)
Appl. No. 17/052,040
Filed by Kartos Therapeutics, Inc., New York, NY (US)
PCT Filed Apr. 30, 2019, PCT No. PCT/US2019/029906
§ 371(c)(1), (2) Date Oct. 30, 2020,
PCT Pub. No. WO2019/213074, PCT Pub. Date Nov. 7, 2019.
Claims priority of provisional application 62/834,848, filed on Apr. 16, 2019.
Claims priority of provisional application 62/781,942, filed on Dec. 19, 2018.
Claims priority of provisional application 62/701,088, filed on Jul. 20, 2018.
Claims priority of provisional application 62/664,673, filed on Apr. 30, 2018.
Prior Publication US 2021/0186946 A1, Jun. 24, 2021
Int. Cl. A61K 31/451 (2006.01); A61K 9/00 (2006.01); A61P 35/00 (2006.01)
CPC A61K 31/451 (2013.01) [A61K 9/0053 (2013.01); A61P 35/00 (2018.01)] 24 Claims
 
1. A method of treating a myeloproliferative neoplasm (MPN) comprising the step of administering to a human subject in need thereof a therapeutically effective amount of a MDM2 inhibitor, wherein the MDM2 inhibitor is a compound of Formula (I):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof.