US 12,444,498 B2
Hemostatic parameter display
Francesco Viola, Charlottesville, VA (US); William F. Walker, Charlottesville, VA (US); Gregory V. Browne, Victoria West (CA); Adam Looker, Victoria (CA); Bryan Roy, Cobble Hill (CA); and Bjarne Hansen, Victoria (CA)
Assigned to HemoSonics LLC, Charlottesville, VA (US)
Filed by HemoSonics LLC, Charlottesville, VA (US)
Filed on Sep. 26, 2022, as Appl. No. 17/935,318.
Application 17/935,318 is a continuation of application No. 16/206,155, filed on Mar. 21, 2019, granted, now 11,456,071.
Application 16/206,155 is a continuation of application No. 13/083,360, filed on Apr. 8, 2011, granted, now 10,147,152.
Claims priority of provisional application 61/322,049, filed on Apr. 8, 2010.
Prior Publication US 2023/0118968 A1, Apr. 20, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. G16H 40/60 (2018.01); A61B 5/145 (2006.01); A61B 5/15 (2006.01); A61B 5/155 (2006.01); G16H 10/60 (2018.01); G16H 15/00 (2018.01)
CPC G16H 40/60 (2018.01) [G16H 10/60 (2018.01); G16H 15/00 (2018.01); A61B 5/14 (2013.01); A61B 5/1405 (2013.01); A61B 5/1427 (2013.01); A61B 5/150343 (2013.01); A61B 5/150755 (2013.01)] 24 Claims
OG exemplary drawing
 
1. A system for measuring physiologic parameters of one or more blood samples, the system comprising:
a receptacle assembly to receive one or more cartridges, including a first cartridge, the first cartridge having:
a plurality of sample wells including a first sample well and a second sample well; and
a plurality of channels including i) a first channel connected in fluid communication to the first sample well and ii) a second channel connected in fluid communication to the second sample well;
wherein the plurality of channels have a collective connection configured to establish fluid communication with at least of the one or more blood samples for drawing, from the one or more blood samples, portions for each of the first and second the sample wells including a first portion for the first sample well and a second portion for the second sample well, respectively;
a sensor system configured to couple with the receptacle assembly for interrogation of the plurality of portions of the one or more blood samples including the first and second portions of the one or more blood samples to yield a plurality of sets of independent measurements including a first set of independent viscoelastic measurements from the first portion and a second set of independent viscoelastic measurements from the second portion;
a processor connected to the sensor system to continually receive the plurality of sets of independent measurements, including a data set associated with the first set of independent viscoelastic measurements and a data sets associated with the second set of independent viscoelastic measurements of the one or more cartridges, the processor being configured, via a set of instructions stored in memory, to estimate physiologic parameters of the one or more samples; and
a graphical user interface (GUI) connected to the processor and configured to display in parallel functional hemostatic indexes derived from each of the plurality of independent measurements, wherein each displayed functional hemostatic index of the simultaneously displayed functional hemostatic indexes comprise a platelet function index representative of samples treated with clopidogrel and a platelet function index representative of samples treated with aspirin, wherein the graphical user interface comprises a graphical indicator for each of the displayed hemostatic indexes, and
wherein the displayed functional hemostatic indexes are used to assess reduced platelet function due to a presence of an antiplatelet drug.