US 12,444,481 B2
Data-analyzing method, data-analyzing device, and sample analyzer
Ikuko Yao, Sanda (JP); Yuzuki Morita, Nagoya (JP); and Shinichi Yamaguchi, Kyoto (JP)
Assigned to SHIMADZU CORPORATION, Kyoto (JP); and KWANSEI GAKUIN EDUCATIONAL FOUNDATION, Nishinomiya (JP)
Filed by SHIMADZU CORPORATION, Kyoto (JP); and KWANSEI GAKUIN EDUCATIONAL FOUNDATION, Nishinomiya (JP)
Filed on Nov. 18, 2022, as Appl. No. 17/989,906.
Claims priority of application No. 2022-066756 (JP), filed on Apr. 14, 2022.
Prior Publication US 2023/0335221 A1, Oct. 19, 2023
Int. Cl. G16B 40/10 (2019.01); G16B 40/30 (2019.01); H01J 49/00 (2006.01); H01J 49/16 (2006.01)
CPC G16B 40/10 (2019.02) [G16B 40/30 (2019.02); H01J 49/0004 (2013.01); H01J 49/0036 (2013.01); H01J 49/164 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A data-analyzing method for instrumental analysis in which an analysis based on a plurality of data groups each obtained by performing a predetermined instrumental analysis on each of a plurality of samples, with each of the plurality of data groups including signal values having an n-dimensional array structure (where n is an integer equal to or greater than two), is performed by using a computer, to obtain desired information concerning a difference between the plurality of samples, the method comprising:
a computational processing step for performing, in each of the plurality of data groups, a persistent-homology processing on data including signal values having an m-dimensional array structure (where m is an integer equal to or greater than two and equal to or less than n) obtained from one data group, to create a persistence diagram; and
an analytical processing step for comparing persistence diagrams respectively obtained from the plurality of data groups with each other, to obtain the desired information based on a difference in a dispersion state of plots across the entire persistence diagrams being compared and/or based on information concerning a plot having no positional correspondence determined on the persistence diagrams being compared;
wherein each of a plurality of data groups are obtained by performing a predetermined instrumental analysis on each of a plurality of samples, with each of the plurality of data groups including signal values having an n-dimensional array structure (where n is an integer equal to or greater than two); and
wherein the instrumental analysis is an imaging analysis employing mass spectrometry or optical spectrometry so as to obtain, the data groups including one of the n dimensions (where n is three or four) is a first parameter representing a mass-to-charge ratio, wavelength or wavenumber, and the remaining n−1 dimensions are information representing a two-dimensional or three-dimensional position on or in a sample.