US 12,442,816 B2
Sensor body for binding and/or enriching and/or detecting an analyte in a sample
Thomas Ellinger, Jena (DE); Eugen Ermantraut, Jena (DE); Katrin Steinmetzer, Jena (DE); Stephan Hubold, Jena (DE); Ivan Loncarevic, Jena (DE); and Torsten Schulz, Jena (DE)
Assigned to BLINK AG, Jena (DE)
Appl. No. 16/957,594
Filed by BLINK AG, Jena (DE)
PCT Filed Dec. 27, 2018, PCT No. PCT/EP2018/097047
§ 371(c)(1), (2) Date Jun. 24, 2020,
PCT Pub. No. WO2019/129825, PCT Pub. Date Jul. 4, 2019.
Claims priority of application No. 17211155 (EP), filed on Dec. 29, 2017.
Prior Publication US 2021/0223236 A1, Jul. 22, 2021
Int. Cl. G01N 33/543 (2006.01); B01J 20/26 (2006.01)
CPC G01N 33/54313 (2013.01) [B01J 20/265 (2013.01); G01N 33/54306 (2013.01)] 5 Claims
OG exemplary drawing
 
1. A method of binding an analyte to a prefabricated particulate sensor body, said method comprising the steps:
a) providing, in any order, a prefabricated particulate sensor body for binding or enriching an analyte, and an aqueous sample suspected of containing an analyte; wherein a diameter of said prefabricated particulate sensor body is in a range of from 1 μm to 1 mm, and wherein said prefabricated particulate sensor body comprises a porous polymeric scaffold and an interstitial pore space within said porous polymeric scaffold, wherein said porous polymeric scaffold is composed of a polymer responsive to a change of at least one external condition to which said prefabricated particulate sensor body is exposed, and wherein one or more capture agents for an analyte is/are attached to said porous polymeric scaffold;
b) exposing said prefabricated particulate sensor body to said aqueous sample, thereby allowing an analyte present in said sample to bind to said prefabricated particulate sensor body and allowing liquid to enter said interstitial pore space of said prefabricated particulate sensor body.