US 12,442,780 B2
Off line quality control of a beam shaping device for radiation therapy
Lucian Hotoiu, Brussels (BE); Rudi Labarbe, Boncelles (BE); François Vander Stappen, Brussels (BE); Julia Pakela, Philadelphia, PA (US); Boonkeng Kevin Teo, Wayne, PA (US); and Wei Zou, Skillman, NJ (US)
Assigned to ION BEAM APPLICATIONS, Louvain-la-Neuve (BE)
Filed by Ion Beam Applications, Louvain-la-neuve (BE); and The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
Filed on Aug. 23, 2023, as Appl. No. 18/454,259.
Claims priority of application No. 22191888 (EP), filed on Aug. 24, 2022.
Prior Publication US 2024/0068963 A1, Feb. 29, 2024
Int. Cl. G01N 23/046 (2018.01); A61N 5/10 (2006.01); B33Y 80/00 (2015.01); G01N 9/24 (2006.01); G01N 23/06 (2018.01)
CPC G01N 23/046 (2013.01) [A61N 5/10 (2013.01); A61N 5/103 (2013.01); A61N 5/1071 (2013.01); B33Y 80/00 (2014.12); G01N 9/24 (2013.01); G01N 23/06 (2013.01); A61N 2005/1095 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A method for assessing a quality of a beam shaping device manufactured according to a planned device design for shaping one or more beams of accelerated particles emitted by a particle accelerator system, the method comprising,
(a) establishing with a treatment planning system (TPS) the planned device design of the beam shaping device suitable for shaping one or more beams of accelerated particles to mate a geometry of a treatment volume (V) of tissue comprising tumoral cells, for depositing specific doses (Dij) into specific locations within the treatment volume (V) thus defining a planned dose distribution (pDD) satisfying objectives on the dose deposition in the treatment volume set by a physician,
(b) manufacturing the beam shaping device according to the planned device design,
(c) establishing a CT-scan of the beam shaping device to yield an actual CT-image,
(d) determining dimensions and local materials densities from the actual CT-image,
(e) extending the actual CT-image to include the treatment volume (V),
(f) determining with a dose engine a calculated dose distribution in the treatment volume (V) obtained by virtually irradiating the treatment volume (V) with the one or more beams through a virtual beam shaping device having a geometry and a density defined by the device actual CT-image, and
(g) comparing the calculated dose distribution (cDD) with a reference dose distribution (rDD).