US 12,442,766 B2
Bond-selective intensity diffraction tomography and uses thereof
Ji-Xin Cheng, Newton, MA (US); Jian Zhao, Boston, MA (US); Lei Tian, Newton, MA (US); and Alex Matlock, Brighton, MA (US)
Assigned to Trustees of Boston University, Boston, MA (US)
Filed by Trustees of Boston University, Boston, MA (US)
Filed on Feb. 21, 2024, as Appl. No. 18/582,748.
Application 18/582,748 is a continuation of application No. 18/100,347, filed on Jan. 23, 2023, granted, now 11,913,881.
Claims priority of provisional application 63/389,582, filed on Jul. 15, 2022.
Prior Publication US 2024/0272074 A1, Aug. 15, 2024
Int. Cl. G01N 21/63 (2006.01); G01N 21/65 (2006.01)
CPC G01N 21/636 (2013.01) [G01N 2021/637 (2013.01); G01N 2021/655 (2013.01)] 22 Claims
OG exemplary drawing
 
1. An imaging system comprising:
an illumination source for providing oblique illuminations to a sample, the illumination source including a plurality of laser elements and a pump laser that are synchronized to produce the oblique illuminations, wherein the plurality of laser elements is arranged to form a ring of laser elements such that each laser element on the ring of laser elements is positioned to produce an oblique illumination on the sample; and
a camera for collecting scattered illuminations from the sample, the camera producing intensity images encoding a volume of the sample for each of the oblique illuminations, wherein the camera captures three-dimensional chemical-specific refractive index (RI) variations of the sample due to the oblique illuminations using the intensity images.