US 12,442,040 B2
Major histocompatibility complex single nucleotide polymorphisms
David Charles Sayer, East Fremantle (AU); Hayley Marianne Hogan, Maylands (AU); and Karolina Mercoulia, Shenton Park (AU)
Assigned to Illumina, Inc., San Diego, CA (US)
Filed by Illumina, Inc., San Diego, CA (US)
Filed on Feb. 15, 2022, as Appl. No. 17/671,951.
Application 17/671,951 is a continuation of application No. 16/362,310, filed on Mar. 22, 2019, granted, now 11,279,976.
Application 16/362,310 is a continuation of application No. 15/029,224, granted, now 10,280,461, issued on May 7, 2019, previously published as PCT/AU2014/000980, filed on Oct. 15, 2014.
Claims priority of application No. 2013903971 (AU), filed on Oct. 15, 2013.
Prior Publication US 2022/0228212 A1, Jul. 21, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C12Q 1/68 (2018.01); C12Q 1/6881 (2018.01); C12Q 1/6883 (2018.01); G01N 27/447 (2006.01)
CPC C12Q 1/6881 (2013.01) [C12Q 1/6883 (2013.01); G01N 27/447 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/16 (2013.01)] 16 Claims
 
1. A method of matching a transplant donor with a transplant recipient, comprising:
a. determining the presence or absence of a single nucleotide polymorphism (SNP) in the transplant donor and in the transplant recipient, wherein the SNP is selected from the group consisting of G12071, A12152, and A14831 of the human complement C4 gene, and wherein the determining comprises hybridizing a SNP primer to a nucleic acid sample from each of the transplant donor and the transplant recipient, wherein the SNP primer comprises a primer consisting of SEQ ID NO: 22, SEQ ID NO: 24, or SEQ ID NO: 37; and
b. matching the transplant donor with the transplant recipient when both the donor and the recipient have the same SNP as one another.