	US 12,442,017 B2
	Microglial selective gene expression vector
Hirokazu Hirai, Gunma (JP); and Yukihiro Okada, Gunma (JP)
Assigned to NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY, Gunma (JP)
Appl. No. 17/908,425
Filed by NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY, Gunma (JP)
PCT Filed Feb. 24, 2021, PCT No. PCT/JP2021/006921 § 371(c)(1), (2) Date Aug. 31, 2022, PCT Pub. No. WO2021/177116, PCT Pub. Date Sep. 10, 2021.
Claims priority of application No. 2020-034991 (JP), filed on Mar. 2, 2020.
Prior Publication US 2023/0399655 A1, Dec. 14, 2023
Int. Cl. C12N 15/86 (2006.01); A61K 48/00 (2006.01)

CPC C12N 15/86 (2013.01) [A61K 48/0058 (2013.01); A61K 48/0075 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14171 (2013.01); C12N 2830/48 (2013.01)]

15 Claims

1. A gene modified adeno-associated viral vector for gene expression in microglia, comprising an expression unit comprising an Iba1 (ionized calcium-binding adaptor molecule 1) promoter, a complementary sequence of miR-9 and a complementary sequence of miR-129.