US 12,441,972 B2
Systems and methods for probe angle adjustment in bioreactors
Prasad Yakkar Kini, Bengaluru (IN); Shashikanth Agnihotry, Bengaluru (IN); Sarath Chandra N, Bengaluru (IN); Vinodkumar Mukuntharaj, Bengaluru (IN); Sairam C, Bengaluru (IN); Prasad Bagiyanathan, Bengaluru (IN); and Kandakumar M., Bengaluru (IN)
Assigned to Cytiva Sweden AB, Uppsala (SE)
Appl. No. 17/611,025
Filed by Cytiva Sweden AB, Uppsala (SE)
PCT Filed May 26, 2020, PCT No. PCT/EP2020/064608
§ 371(c)(1), (2) Date Nov. 12, 2021,
PCT Pub. No. WO2020/239786, PCT Pub. Date Dec. 3, 2020.
Claims priority of application No. 201911021316 (IN), filed on May 29, 2019.
Prior Publication US 2022/0243159 A1, Aug. 4, 2022
Int. Cl. C12M 3/00 (2006.01); C12M 1/00 (2006.01); C12M 1/06 (2006.01); C12M 1/36 (2006.01)
CPC C12M 23/48 (2013.01) [C12M 23/14 (2013.01); C12M 27/02 (2013.01); C12M 41/48 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A system comprising:
a reactor vessel comprising a reaction chamber, wherein the reaction chamber has a plurality of respective openings; and
a probe support bar assembly mounted on the reactor vessel and a plurality of sensing probes mounted in a plurality of rows, wherein each sensing probe passes through one of the respective openings on the reaction chamber and wherein movement of the probe support bar assembly changes an angle of inclination of the plurality of sensing probes, wherein the probe support bar assembly comprises:
a moveable part including a probe support bar mounted on one or more probe support legs;
a linear bush holder having an index plunger engageable with a plurality of holes; and
a fixed part including a linear shaft holder having two or more linear rods for slideable engagement with the linear bush holder and the plurality of holes for holding the index plunger, wherein a height adjustment is provided by relative movement between the linear shaft holder and the linear bush holder,
wherein the index plunger is mounted on the moveable part and the holes are affixed to the reactor vessel.