US 12,441,837 B2
Immobilization of phenolic compounds
Andreas Gram, Höör (SE); Oskar Axelsson, Höör (SE); and Rikard Larsson, Tagarp (SE)
Assigned to Spago Nanomedical AB, Lund (SE)
Appl. No. 17/780,839
Filed by Spago Nanomedical AB, Lund (SE)
PCT Filed Dec. 16, 2020, PCT No. PCT/EP2020/086591
§ 371(c)(1), (2) Date May 27, 2022,
PCT Pub. No. WO2021/122859, PCT Pub. Date Jun. 24, 2021.
Claims priority of application No. 19216697 (EP), filed on Dec. 16, 2019.
Prior Publication US 2023/0039790 A1, Feb. 9, 2023
Int. Cl. C08G 65/30 (2006.01); C08G 65/336 (2006.01)
CPC C08G 65/30 (2013.01) [C08G 65/336 (2013.01)] 13 Claims
 
1. A method of immobilizing a phenolic compound having a Mw≥500 g/mol, wherein the method comprises the steps of:
ionizing the phenolic compound by subjecting it to a base; and
contacting, under agitation, the ionized phenolic compound with a cross-linked resin comprising the functionality of —C(═O)—CHXCH2R, wherein X is selected from the group consisting of Br, Cl, I, CN, OMs, OTs, and OTf; and R is H, CH3 or a branched or unbranched alkyl having 1 to 8 carbon atoms.