	US 12,441,808 B2
	Antibody polypeptides and uses thereof
Amanda Thuy Tran, Malmo (SE); Anders Axelsson, Bjärred (SE); Cecilia Ann-Christin Malmborg Hager, Helsingborg (SE); Kjell Sjöström, Lund (SE); Sven-Erik Strand, Lund (SE); and Urpo Juhani Lamminmäki, Vanhalinna (FI)
Assigned to FREDAX AB, Bjarred (SE)
Filed by FREDAX AB, Bjarred (SE)
Filed on Apr. 11, 2022, as Appl. No. 17/717,254.
Application 17/717,254 is a division of application No. 15/761,260, granted, now 11,332,543, previously published as PCT/EP2016/073684, filed on Oct. 4, 2016.
Claims priority of application No. 1517550 (GB), filed on Oct. 5, 2015; and application No. 1519105 (GB), filed on Oct. 29, 2015.
Prior Publication US 2022/0242969 A1, Aug. 4, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/30 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 47/68 (2017.01); A61K 51/10 (2006.01); A61P 35/00 (2006.01); G01N 33/574 (2006.01)

CPC C07K 16/3069 (2013.01) [A61K 39/395 (2013.01); A61K 47/6869 (2017.08); A61K 51/1072 (2013.01); A61K 51/1096 (2013.01); A61P 35/00 (2018.01); G01N 33/57434 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/54 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01); C07K 2317/624 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01)]

19 Claims

1. An isolated nucleic acid molecule encoding an antibody polypeptide with binding specificity for prostate specific antigen (PSA), wherein the antibody polypeptide comprises

(i) a heavy chain variable region comprising the amino acid sequences of SEQ ID NO:1 and SEQ ID NO:2 and SEQ ID NO:3; and

(ii) a light chain variable region comprising the amino acid sequences of SEQ ID NO:4 and SEQ ID NO:5 and SEQ ID NO:6,

wherein the heavy chain variable region and light chain variable region comprise framework amino acid sequences from one or more human antibodies.