	US 12,441,800 B2
	Bispecific anti-PSMA x anti-CD28 antibodies and uses thereof
Andrew J. Murphy, Croton-on-Hudson, NY (US); Dimitris Skokos, New York, NY (US); Janelle Waite, Bronx, NY (US); Erica Ullman, Yorktown Heights, NY (US); Aynur Hermann, New York, NY (US); Eric Smith, New York, NY (US); Lauric Haber, Rye Brook, NY (US); and George D. Yancopoulos, Yorktown Heights, NY (US)
Assigned to Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US)
Filed by Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US)
Filed on Dec. 7, 2022, as Appl. No. 18/077,137.
Application 18/077,137 is a continuation of application No. 16/448,462, filed on Jun. 21, 2019, granted, now 11,548,947.
Claims priority of provisional application 62/815,878, filed on Mar. 8, 2019.
Claims priority of provisional application 62/781,930, filed on Dec. 19, 2018.
Claims priority of provisional application 62/781,980, filed on Dec. 19, 2018.
Claims priority of provisional application 62/688,227, filed on Jun. 21, 2018.
Prior Publication US 2023/0272078 A1, Aug. 31, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/28 (2006.01); A61K 39/00 (2006.01); C07K 16/30 (2006.01)

CPC C07K 16/2818 (2013.01) [C07K 16/3069 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/565 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01); C07K 2317/74 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01)]

14 Claims

1. An isolated host cell comprising:

a recombinant expression vector comprising a nucleic acid molecule encoding a first heavy chain variable region (HCVR) comprising HCDR1, HCDR2, HCDR3 domains, respectively, comprising the amino acid sequences of SEQ ID NOs: 12, 14 and 16;

a recombinant expression vector comprising a nucleic acid molecule encoding a second HCVR comprising HCDR1, HCDR2, HCDR3 domains, respectively, comprising the amino acid sequences of SEQ ID NOs: 4, 6 and 8; and

a recombinant expression vector comprising a nucleic acid molecule encoding a light chain variable region (LCVR) comprising LCDR1, LCDR2, LCDR3 domains, respectively, comprising the amino acid sequences of SEQ ID NOs: 20, 22 and 24.