US 12,441,778 B2
T cell receptors recognizing HLA-A1-restricted MAGE-A3
Paul F. Robbins, Chevy Chase, MD (US); Steven A. Rosenberg, Potomac, MD (US); Shiqui Zhu, Potomac, MD (US); Steven A. Feldman, Redwood City, CA (US); and Richard A. Morgan, Center Harbor, NH (US)
Assigned to The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US)
Filed by The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US)
Filed on Mar. 10, 2022, as Appl. No. 17/691,569.
Application 16/144,226 is a division of application No. 14/344,354, abandoned, previously published as PCT/US2012/054623, filed on Sep. 11, 2012.
Application 17/691,569 is a continuation of application No. 16/144,226, filed on Sep. 27, 2018, granted, now 11,306,131.
Claims priority of provisional application 61/535,086, filed on Sep. 15, 2011.
Prior Publication US 2022/0195008 A1, Jun. 23, 2022
Int. Cl. C07K 14/725 (2006.01); A61K 40/11 (2025.01); A61K 40/32 (2025.01); A61K 40/42 (2025.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); G01N 33/574 (2006.01)
CPC C07K 14/70503 (2013.01) [A61K 40/11 (2025.01); A61K 40/32 (2025.01); A61K 40/4268 (2025.01); A61K 40/4269 (2025.01); C07K 14/7051 (2013.01); C07K 16/2803 (2013.01); G01N 33/574 (2013.01); G01N 33/57407 (2013.01); C07K 2317/73 (2013.01); C07K 2318/20 (2013.01)] 22 Claims
 
1. An isolated or purified nucleic acid comprising a nucleotide sequence encoding a T cell receptor (TCR) having antigenic specificity for melanoma antigen family A (MAGE A)-3 in the context of HLA-A1, wherein the TCR comprises the amino acid sequences of (a) SEQ ID NOs: 5-10 or (b) SEQ ID NOs: 16-21.