US 12,441,775 B2
BCL-W polypeptides and mimetics for treating or preventing chemotherapy-induced peripheral neuropathy and hearing loss
Rosalind Segal, Brookline, MA (US); Loren D. Walensky, Newton, MA (US); Lisa V. Goodrich, Newton, MA (US); Sarah Elizabeth Raissi, Waltham, MA (US); Maria F. Murphy, Revere, MA (US); and Gregory H. Bird, Pelham, NH (US)
Assigned to Dana-Farber Cancer Institute, Inc., Boston, MA (US); and President and Fellows of Harvard College, Cambridge, MA (US)
Filed by Dana-Farber Cancer Institute, Inc., Boston, MA (US); and President and Fellows of Harvard College, Cambridge, MA (US)
Filed on Aug. 29, 2022, as Appl. No. 17/823,018.
Application 17/823,018 is a division of application No. 16/326,493, granted, now 11,466,064, previously published as PCT/US2017/048582, filed on Aug. 25, 2017.
Claims priority of provisional application 62/380,048, filed on Aug. 26, 2016.
Prior Publication US 2023/0077821 A1, Mar. 16, 2023
Int. Cl. C07K 14/47 (2006.01); A61K 31/337 (2006.01); A61K 38/00 (2006.01); A61K 38/10 (2006.01); A61K 38/17 (2006.01); A61K 45/06 (2006.01); A61P 25/02 (2006.01); A61P 27/16 (2006.01); A61P 35/00 (2006.01); C07K 7/08 (2006.01)
CPC C07K 14/4747 (2013.01) [A61K 31/337 (2013.01); A61K 38/10 (2013.01); A61P 25/02 (2018.01); A61P 27/16 (2018.01); A61P 35/00 (2018.01); C07K 7/08 (2013.01); A61K 38/00 (2013.01); A61K 38/1761 (2013.01); A61K 45/06 (2013.01)] 17 Claims
 
1. A method of treating hearing loss in a human subject in need thereof, the method comprising administering to the human subject an effective amount of a Bcl-2-like protein 2 (bclw) mimetic, wherein the bclw mimetic is an internally cross-linked polypeptide comprising the amino acid sequence of SEQ ID NO: 15, wherein position 12 of SEQ ID NO: 15 is internally cross-linked to position 16 of SEQ ID NO:15.