	US 12,441,774 B2
	Molecular guide system peptides and uses thereof
Kathlynn C. Brown, Staunton, VA (US); Nathan Collins, Menlo Park, CA (US); Shunzi “Susan” Li, Harrisonburg, VA (US); Curtis Allred, Menlo Park, CA (US); Keen Chung, Menlo Park, CA (US); and Michael McGuire, Menlo Park, CA (US)
Assigned to SRI International, Menlo Park, CA (US)
Filed by SRI International, Menlo Park, CA (US)
Filed on Dec. 20, 2023, as Appl. No. 18/390,354.
Application 18/390,354 is a division of application No. 16/629,799, granted, now 11,965,004, previously published as PCT/US2018/041403, filed on Jul. 10, 2018.
Claims priority of provisional application 62/530,633, filed on Jul. 10, 2017.
Prior Publication US 2024/0209041 A1, Jun. 27, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/47 (2006.01); A61K 47/64 (2017.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01); A61K 38/00 (2006.01)

CPC C07K 14/4702 (2013.01) [A61K 47/64 (2017.08); A61P 35/00 (2018.01); C07K 16/2803 (2013.01); A61K 38/00 (2013.01)]

14 Claims

1. A composition comprising an antibody conjugated to a molecular guidance system (MGS) peptide, directly or via a linker, wherein the MGS peptide is selected from the group consisting of:

YAAWPASGAWT (SEQ ID NO: 6), D-Leu-RGDLATLRQL (SEQ ID NO: 8), LQWRRNFGVWARYRL (SEQ ID NO: 31), KQYATPRVFWT (SEQ ID NO: 33), CH₃CO-YAAWPASGAWT-PEG₁₁-C-NH₂(SEQ ID NO: 71), CH₃CO-LQWRRNFGVWARYRL -PEG₁₁-C-NH₂(SEQ ID NO: 72), CH₃CO-RGDLATLRQL-PEG₁₁-YC-NH₂(SEQ ID NO: 73), CH₃CO-D-Leu-RGDLATLRQL-PEG₁₁-YC-NH₂(SEQ ID NO: 74), CH₃CO-FHAVPQSFYT (SEQ ID NO: 80), CH₃CO-D-Leu-RGDLATLRQL (SEQ ID NO: 81), CH3CO -YAAWPASGAWT (SEQ ID NO: 82), CH₃CO-KQYATPRVFWT (SEQ ID NO: 84), and CH₃CO-LQWRRNFGVWARYRL (SEQ ID NO: 85).