US 12,441,773 B2
Peptides, hydrogel compositions and methods of use thereof
Sven-Ulrik Gorr, Minneapolis, MN (US); Conrado Aparicio, Minneapolis, MN (US); and Zhou Ye, Minneapolis, MN (US)
Assigned to REGENTS OF THE UNIVERSITY OF MINNESOTA, Minneapolis, MN (US)
Filed by Regents of the University of Minnesota, Minneapolis, MN (US)
Filed on Jun. 5, 2024, as Appl. No. 18/734,820.
Application 18/734,820 is a continuation of application No. 17/098,629, filed on Nov. 16, 2020, granted, now 12,037,374.
Claims priority of provisional application 62/936,118, filed on Nov. 15, 2019.
Prior Publication US 2025/0074956 A1, Mar. 6, 2025
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/47 (2006.01); A61K 47/10 (2017.01)
CPC C07K 14/47 (2013.01) [A61K 47/10 (2013.01)] 12 Claims
 
1. A hydrogel structure material consisting of a BPI Fold Containing Family A Member 2 (BPIFA2) peptide of 13 to 50 amino acids in length comprising the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, or SEQ ID NO: 13, wherein the hydrogel structure material is formed by contacting the peptide with an alkaline solution, and wherein the peptide is at a concentration above 0.8 mg/ml.