US 12,441,768 B2
Compositions and methods for treating endometriosis
Tanya Petrossian, Laguna Niguel, CA (US); Stephen Fiacco, Laguna Niguel, CA (US); Tristin Rose, Laguna Niguel, CA (US); Amanda Hardy, Laguna Niguel, CA (US); Keerthi Boddupally, Laguna Niguel, CA (US); and Matthew Willmore, Laguna Niguel, CA (US)
Assigned to Endomet Biosciences, Inc., Irvine, CA (US)
Filed by EndoMet Biosciences, Inc., Irvine, CA (US)
Filed on Nov. 30, 2023, as Appl. No. 18/524,461.
Application 18/524,461 is a continuation of application No. 17/295,377, granted, now 11,884,749, previously published as PCT/US2019/062679, filed on Nov. 21, 2019.
Claims priority of provisional application 62/770,601, filed on Nov. 21, 2018.
Prior Publication US 2024/0228540 A1, Jul. 11, 2024
Int. Cl. C07K 7/08 (2006.01); A61K 38/00 (2006.01); A61P 15/02 (2006.01)
CPC C07K 7/08 (2013.01) [A61P 15/02 (2018.01); A61K 38/00 (2013.01)] 23 Claims
 
1. A peptide comprising the amino acid sequence of formula R-X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16, wherein:
R is stearic acid, palmitic acid, myristic acid, lauric acid, a C1-C8 hydrocarbon, a C1-C8 fatty acid, or null;
X1 is M, G, beta alanine, norleucine, norvaline, or null;
X2 is W, N-methyl W, R, Y, F, citrulline, or K,
X3 is P, W, N-methyl-W, N-ethyl-W, N-methyl A, N-ethyl A, L, Pip, Aib, Y, or F;
X4 is E, Q, N, or D;
X5 is S, alpha methyl S, K, D, Orn, T, or E;
X6 is I, Chg, H, or L;
X7 is L or I;
X8 is D, N, E, or Q;
X9 is D, E, K, Q, or Orn;
X10 is H or methyl-H;
X11 is V, alpha methyl V, Chg, L, I, or norvaline;
X12 is Q, Aib, S, R, or N;
X13 is R, K, citrulline, Orn, D, or E;
X14 is V, I, L, or norvaline;
X15 is W, Y, or F; and
X16 is R, G, or null, wherein the amino acid sequence is circularized with an amide bond, and wherein the amide bond is (1) head-to-tail between N-terminus and C-terminus, (2) head-to-side chain between N-terminus and an internal COOH, (3) side chain-to-tail between an internal NH2 and C-terminus, or (4) side chain-to-side chain between an internal NH2 and an internal COOH.