US 12,441,758 B2
Cobalamin derivatives and their use for the treatment of diseases caused by lack of vitamin B12 supply
Luciana Hannibal, Voerstetten (DE)
Assigned to Albert-Ludwigs-Universitaet Freiburg, Freiburg (DE)
Filed by Albert-Ludwigs-Universitaet Freiburg, Freiburg (DE)
Filed on Jun. 3, 2022, as Appl. No. 17/832,112.
Application 17/832,112 is a continuation of application No. 16/615,014, granted, now 11,384,113, previously published as PCT/EP2018/063597, filed on May 24, 2018.
Claims priority of application No. 17172613 (EP), filed on May 24, 2017.
Prior Publication US 2022/0372064 A1, Nov. 24, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07H 23/00 (2006.01); A23L 33/15 (2016.01)
CPC C07H 23/00 (2013.01) [A23L 33/15 (2016.08); A23V 2002/00 (2013.01)] 13 Claims
 
1. A cobalamin derivative of Formula (I) shown below,

OG Complex Work Unit Chemistry
wherein X is a ligand having a formula selected from the group consisting of:
(CH2)1-5—S—(CH2)0-3—CH3, —S—(CH2)1-5—NH2 and

OG Complex Work Unit Chemistry
wherein R1 is H, methyl or ethyl, R2 is ═O and R3 is H or

OG Complex Work Unit Chemistry