	US 12,441,735 B2
	Nitrogen-containing heterocyclic compound having NRF2 activation effect
Atsushi Kimbara, Kamakura (JP); Takeo Harada, Gotemba (JP); Susumu Komiyama, Kamakura (JP); Mizuki Okuyama, Kamakura (JP); Yoshihito Ohtake, Gotemba (JP); Yoshihisa Murata, Gotemba (JP); and Rie Saito, Kamakura (JP)
Assigned to CHUGAI SEIYAKU KABUSHIKI KAISHA, Tokyo (JP)
Filed by CHUGAI SEIYAKU KABUSHIKI KAISHA, Tokyo (JP)
Filed on Jan. 21, 2025, as Appl. No. 19/033,289.
Application 19/033,289 is a continuation of application No. 18/726,155, previously published as PCT/JP2023/000211, filed on Jan. 6, 2023.
Claims priority of application No. 2022-001804 (JP), filed on Jan. 7, 2022.
Prior Publication US 2025/0171457 A1, May 29, 2025
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 491/08 (2006.01); A61K 31/472 (2006.01); A61K 31/4725 (2006.01); A61K 31/502 (2006.01); A61K 31/536 (2006.01); A61K 31/5365 (2006.01); A61K 31/5377 (2006.01); A61K 31/538 (2006.01); A61K 31/5383 (2006.01); A61K 31/5386 (2006.01); A61K 31/541 (2006.01); A61K 31/5415 (2006.01); A61K 31/55 (2006.01); A61K 31/551 (2006.01); C07D 217/06 (2006.01); C07D 237/32 (2006.01); C07D 265/02 (2006.01); C07D 265/16 (2006.01); C07D 401/10 (2006.01); C07D 401/14 (2006.01); C07D 403/10 (2006.01); C07D 413/10 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/10 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 487/10 (2006.01); C07D 491/107 (2006.01); C07D 519/00 (2006.01)

CPC C07D 491/08 (2013.01) [A61K 31/472 (2013.01); A61K 31/4725 (2013.01); A61K 31/502 (2013.01); A61K 31/536 (2013.01); A61K 31/5365 (2013.01); A61K 31/5377 (2013.01); A61K 31/538 (2013.01); A61K 31/5383 (2013.01); A61K 31/5386 (2013.01); A61K 31/541 (2013.01); A61K 31/5415 (2013.01); A61K 31/55 (2013.01); A61K 31/551 (2013.01); C07D 217/06 (2013.01); C07D 237/32 (2013.01); C07D 265/02 (2013.01); C07D 265/16 (2013.01); C07D 401/10 (2013.01); C07D 401/14 (2013.01); C07D 403/10 (2013.01); C07D 413/10 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/10 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 487/10 (2013.01); C07D 491/107 (2013.01); C07D 519/00 (2013.01)]

28 Claims

1. A compound selected from the following compounds, or a salt thereof, or a solvate thereof:

4-[3-[2,6-dichloro-4-[(2R)-2,4-dimethylpiperazin-1-yl]benzoyl]-2,4-dihydro-1,3-benzoxazin-8-yl]-5-fluoro-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)benzoic acid,

4-[3-[2,6-dichloro-4-(7,7-dimethyl-5,9-dioxa-2-azaspiro[3.5]nonan-2-yl)benzoyl]-2,4-dihydro-1,3-benzoxazin-8-yl]-5-fluoro-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)benzoic acid,

4-[3-[2,6-dichloro-4-(6-methoxy-2-azaspiro[3.3]heptan-2-yl)benzoyl]-2,4-dihydro-1,3-benzoxazin-8-yl]-5-fluoro-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)benzoic acid,

4-[3-[2-chloro-4-[(2R,5R)-2,4,5-trimethylpiperazin-1-yl]benzoyl]-2,4-dihydro-1,3-benzoxazin-8-yl]-5-fluoro-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)benzoic acid, and

4-[3-[4-chloro-6-(7,7-dimethyl-5,9-dioxa-2-azaspiro[3.5]nonan-2-yl)-2-methylpyridine-3-carbonyl]-2,4-dihydro-1,3-benzoxazin-8-yl]-5-fluoro-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)benzoic acid.