US 12,441,729 B2
Process for preparing 7-chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
Michal Achmatowicz, San Diego, CA (US); John T. Colyer, Newbury Park, CA (US); Michael T. Corbett, San Carlos, CA (US); Daniel J. Griffin, Cambridge, MA (US); Andrew T. Parsons, Cambridge, MA (US); Joanna Robinson, Los Angeles, CA (US); and Kyle Quasdorf, Thousand Oaks, CA (US)
Assigned to AMGEN INC., Thousand Oaks, CA (US)
Filed by AMGEN INC., Thousand Oaks, CA (US)
Filed on Dec. 19, 2024, as Appl. No. 18/987,521.
Application 18/987,521 is a continuation of application No. 18/253,285, previously published as PCT/US2021/060048, filed on Nov. 19, 2021.
Claims priority of provisional application 63/116,703, filed on Nov. 20, 2020.
Prior Publication US 2025/0129072 A1, Apr. 24, 2025
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 471/04 (2006.01)
CPC C07D 471/04 (2013.01) 22 Claims
 
1. A process of preparing compound A

OG Complex Work Unit Chemistry
comprising:
(a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C);
(b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl) carbamoyl) nicotinamide (Compound E); and
(c) admixing Compound E and a second base to form a product mixture comprising Compound A.