US 12,441,728 B2
Pyridazine compounds for inhibiting NLRP3
Stéphane Dorich, Pointe-Claire (CA)
Assigned to Ventus Therapeutics U.S., Inc., Waltham, MA (US)
Filed by Ventus Therapeutics U.S., Inc., Waltham, MA (US)
Filed on Oct. 4, 2023, as Appl. No. 18/480,925.
Application 18/480,925 is a continuation of application No. 18/480,164, filed on Oct. 3, 2023.
Application 18/480,164 is a continuation of application No. PCT/US2022/023893, filed on Apr. 7, 2022.
Claims priority of provisional application 63/171,932, filed on Apr. 7, 2021.
Prior Publication US 2024/0174668 A1, May 30, 2024
Int. Cl. C07D 471/04 (2006.01); A61K 31/501 (2006.01); A61K 31/502 (2006.01); A61K 31/5025 (2006.01); A61K 31/5377 (2006.01); C07D 405/12 (2006.01); C07D 491/048 (2006.01); C07D 495/04 (2006.01); C07D 519/00 (2006.01)
CPC C07D 471/04 (2013.01) [A61K 31/501 (2013.01); A61K 31/502 (2013.01); A61K 31/5025 (2013.01); A61K 31/5377 (2013.01); C07D 405/12 (2013.01); C07D 491/048 (2013.01); C07D 495/04 (2013.01); C07D 519/00 (2013.01)] 7 Claims
 
1. A compound of Formula (II):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt, solvate, clathrate, hydrate, stereoisomer, or tautomer thereof, wherein:
Y is phenyl independently substituted with one or more C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, halo, cyano, or —R4OR5, wherein at least one substitution is substituted at the para-position of the phenyl ring;
R1 is
5- to 9- membered heteroaryl optionally substituted with one or more halo, —R4OR5, an optionally substituted 3- to 8-membered heterocycloalkyl, an optionally substituted C5-C10 aryl, or an optionally substituted 5- to 9-membered heteroaryl;
R2 and R3, together with the atoms to which they are attached, form a 5- to 9-membered heteroaryl optionally substituted with one or more R2a;
R2a is hydrogen, C1-C6 alkyl, halo or C1-C6 haloalkyl;
R4 is absent, C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl; and
R5 is hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, 3- to 8-membered heterocycloalkyl, C5-C10 aryl, or 5- to 9-membered heteroaryl.