US 12,441,722 B2
Therapeutic agents and methods of treatment
Guangrong Zheng, Gainesville, FL (US); Daohong Zhou, Gainesville, FL (US); Xuan Zhang, Gainesville, FL (US); Wanyi Hu, Gainesville, FL (US); Xingui Liu, Gainesville, FL (US); Dongwen Lyu, Gainesville, FL (US); Yaxia Yuan, Gainesville, FL (US); and Dinesh Thummuri, Gainesville, FL (US)
Assigned to University of Florida Research Foundation, Incorporated, Gainesville, FL (US)
Appl. No. 17/790,211
Filed by University of Florida Research Foundation, Incorporated, Gainesville, FL (US)
PCT Filed Jan. 15, 2021, PCT No. PCT/US2021/013602
§ 371(c)(1), (2) Date Jun. 30, 2022,
PCT Pub. No. WO2021/146536, PCT Pub. Date Jul. 22, 2021.
Claims priority of provisional application 62/961,330, filed on Jan. 15, 2020.
Prior Publication US 2023/0339929 A1, Oct. 26, 2023
Int. Cl. C07D 417/14 (2006.01); A61K 31/4725 (2006.01); A61K 45/06 (2006.01); A61P 35/02 (2006.01)
CPC C07D 417/14 (2013.01) [A61K 31/4725 (2013.01); A61K 45/06 (2013.01); A61P 35/02 (2018.01)] 22 Claims
 
1. A compound of Formula (I), or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof:
Y-L2-R-L1-Y2  Formula (I);
wherein L1 is independently

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 or absent;
R is independently optionally substituted C1-50 alkylene or optionally substituted C1-50 heteroalkylene wherein:
optionally one or more backbone carbon atoms of each instance of the optionally substituted alkylene or optionally substituted heteroalkylene are independently replaced with —C(═O)O—, —OC(═O)—, —NHC(═O)—, —C(═O)NH—, optionally substituted cycloalkylene, optionally substituted heterocycloalkylene, optionally substituted arylene, or optionally substituted heteroarylene; and
optionally one or more backbone heteroatoms of each instance of the optionally substituted heteroalkylene are independently replaced with optionally substituted cycloalkylene, optionally substituted heterocycloalkylene, optionally substituted arylene, or optionally substituted heteroarylene;
L2 is independently

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Y is independently

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Y2 is independently

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each R2 is independently H, optionally substituted alkyl, or optionally substituted cycloalkyl;
each R3 is hydrogen,

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each R4 is independently H, optionally substituted alkyl, or optionally substituted cycloalkyl;
each R5 is independently H, optionally substituted alkyl, or optionally substituted cycloalkyl; and
r is 0-10, inclusive.